https://scholars.lib.ntu.edu.tw/handle/123456789/568075
標題: | Systemic immunity-enhancing effects in healthy subjects following dietary consumption of the lactic acid bacterium Lactobacillus rhamnosus HN001 | 作者: | Sheih Y.-H. BOR-LUEN CHIANG Wang L.-H. Liao C.-K. Gill H.S. |
關鍵字: | Immune enhancement; Lactobacillus rhamnosus; NK cells; Phagocytosis | 公開日期: | 2001 | 卷: | 20 | 期: | 2 | 起(迄)頁: | 149-156 | 來源出版物: | Journal of the American College of Nutrition | 摘要: | Objective: To determine the effects of the probiotic lactic acid bacterium, Lactobacillus rhamnosus HN001, on natural cellular immunity when delivered orally in normal low-fat milk (LFM) or lactose-hydrolyzed low-fat milk (LFM-LH). Design: A three stage, pre-post intervention trial, spanning nine weeks. Setting: Taipei Medical College Hospital, Taipei, Taiwan. Subjects: Fifty-two healthy middle-aged and elderly volunteers (17 males, 35 females; median age 63.5, range 44-80). Interventions: Stage 1 (run-in diet): 25g/200 mL reconstituted LFM powder, twice dally for 3 weeks. Stage 2 (probiotic intervention): LFM or LFM-LH, supplemented with 109 CFUs/g L. rhamnosus HN001 in each case, for 3 weeks. Stage 3 (wash-out): LFM for 3 weeks. Measures of Outcome: In vitro phagocytic capacity of peripheral blood polymorphonuclear (PMN) leukocytes; in vitro tumoricidal activity of natural killer (NK) leukocytes. Results: Immunological responses were unaffected by the run-in diet of LFM alone. In contrast, the relative proportion of PMN cells showing phagocytic activity increased by 19% and 15%, respectively, following consumption of HN001 in either LFM or LFM-LH; the relative level of NK cell tumor killing activity increased by 71% and 147%. In most cases these levels declined following cessation, but remained above baseline. Conclusions: Dietary consumption of L. rhamnosus HN001, in a base of low-fat milk or lactose-hydrolyzed low-fat milk, appears to enhance systemic cellular immune responses and may be useful as a dietary supplement to boost natural immunity. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0035001855&doi=10.1080%2f07315724.2001.10719027&partnerID=40&md5=46a8bfa6f04fe9f234683fe649649938 https://scholars.lib.ntu.edu.tw/handle/123456789/568075 |
ISSN: | 0731-5724 | DOI: | 10.1080/07315724.2001.10719027 | SDG/關鍵字: | adult; aged; antineoplastic activity; article; cellular immunity; controlled study; dietary intake; female; human; human cell; human experiment; lactic acid bacterium; Lactobacillus rhamnosus; leukocyte; male; milk; natural killer cell; normal human; phagocytosis; polymorphonuclear cell; Adult; Aged; Aged, 80 and over; Animals; Double-Blind Method; Female; Humans; Immunity, Cellular; Killer Cells, Natural; Lactobacillus; Male; Middle Aged; Milk; Neutrophils; Phagocytosis; Probiotics; Taiwan; Bacteria (microorganisms); Lactobacillus rhamnosus |
顯示於: | 醫學系 |
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