Association Between High Levels of Hepatitis B Core Antibody and Seroclearance of Hepatitis B e Antigen in Individuals With Chronic Hepatitis B Virus Infection
Journal
Clinical Gastroenterology and Hepatology
Journal Volume
17
Journal Issue
7
Pages
1413-1415
Date Issued
2019
Author(s)
Liu J.
Hu H.-H.
Chang C.-L.
Jen C.-L.
Lee M.-H.
Lu S.-N.
Wang L.-Y.
Yuan Q.
Xia N.-S.
Sugiyama M.
Nishida N.
Mizokami M.
Chen C.-J.
Yang H.-I.
Abstract
For chronic hepatitis B patients, hepatitis B e antigen (HBeAg) seroclearance signals a transition from an immunologically active phase to an inactive carrier state with a reduction in hepatitis B virus (HBV) DNA levels and a reduced risk of hepatocellular carcinoma (HCC).1 Predictors of HBeAg seroclearance include lower HBV DNA levels, viral genotype, the precore mutation, and higher serum alanine aminotransferase (ALT) levels.2 ? 2019 AGA Institute
SDGs
Other Subjects
hepatitis B core antibody; hepatitis B(e) antigen; hepatitis B antibody; hepatitis B surface antigen; virus DNA; adult; antibody blood level; antibody detection; chronic hepatitis B; cohort analysis; controlled study; female; hepatic clearance; human; incidence; major clinical study; male; middle aged; predictive value; Short Survey; virus load; chronic hepatitis B; enzyme immunoassay; follow up; genetics; genotype; Hepatitis B virus; immunology; metabolism; prognosis; retrospective study; time factor; virology; virus load; DNA, Viral; Follow-Up Studies; Genotype; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunoenzyme Techniques; Prognosis; Retrospective Studies; Time Factors; Viral Load
Publisher
W.B. Saunders
Type
short survey