Nucleocapsid phosphorylation and RNA helicase DDX1 recruitment enables coronavirus transition from discontinuous to continuous transcription
Journal
Cell Host and Microbe
Journal Volume
16
Journal Issue
4
Pages
462-472
Date Issued
2014
Author(s)
Abstract
GSK-3 inhibitor reduces coronavirus nucleocapsid phosphorylation (pN) and titerpN recruits RNA helicase DDX1 and is crucial for long sgmRNA and gRNA synthesisDDX1 knockdown or loss of helicase activity impairs longer sgmRNAs synthesispN/DDX1 bind to viral genome and assist template readthrough of viral body TRSs
Publisher
Cell Press
Type
journal article