Serum interleukin 6 level correlates with outcomes of acute exacerbation of chronic hepatitis B
Journal
Hepatology International
Journal Volume
6
Journal Issue
3
Pages
591-597
Date Issued
2012
Author(s)
Pan C.J.-H.
Wu H.-L.
Kuo S.F.-T.
Abstract
Purpose Acute exacerbation (AE) of chronic hepatitis B virus (HBV) infection is common and negatively impacts the clinical outcome. Factors predicting outcomes after exacerbations were only partly clarified. We investigated the host immune parameters associated with long-term outcomes. Methods We prospectively examined the profiles of serum cytokines and chemokines in 36 consecutive hepatitis B e antigen (HBeAg)-positive patients (male 72%, age 40.8 ± 9.9 years, genotype B/C 75%/25%) who developed AE in a medical center. The patients were followed up for a median of 4 years (range 2-6 years) post-AE. The impact of six cytokines (tumor necrosis factor alfa, interferon gamma, IL-2, IL-4, IL-6, and IL-10) and five chemokines (CXCL10/IP-10, CCL2/MCP-1, CXCL9/MIG, CCL5/ RANTES, and CXCL8/IL-8) at the onset of AE activity on the long-term outcomes were analyzed. Results Of 36 patients, 22 (61.1%) developed HBeAg seroconversion during follow-up (Group I), and the remaining 14 patients did not obtain HBeAg seroconversion (Group II). Baseline characteristics were generally similar between two groups of patients. In Group I patients, the frequency of undetectable serum IL-6 level (<3 pg/mL) at the onset of AE was significantly higher in comparison with Group II patients in multivariate analysis (86.4 vs. 42.9%, P = 0.016). Conclusions Our findings indicate that undetectable serum IL-6 level at the early stage of AE correlated with the longterm outcomes and may serve as a useful clinical predictor. ? Asian Pacific Association for the Study of the Liver 2011.
SDGs
Other Subjects
CXCL9 chemokine; gamma interferon; gamma interferon inducible protein 10; hepatitis B(e) antigen; interleukin 10; interleukin 2; interleukin 4; interleukin 6; interleukin 8; lamivudine; monocyte chemotactic protein 1; RANTES; tumor necrosis factor alpha; virus DNA; adult; article; cytokine response; disease exacerbation; disease severity; female; follow up; genotype; hepatitis B; Hepatitis B virus; human; male; outcome assessment; priority journal; prognosis; prospective study; protein blood level; remission; seroconversion
Publisher
Springer New York LLC
Type
journal article