https://scholars.lib.ntu.edu.tw/handle/123456789/568521
標題: | Association of IL28B gene variations with mathematical modeling of viral kinetics in chronic hepatitis C patients with IFN plus ribavirin therapy | 作者: | Hsu C.-S. SHIH-JER HSU Chen H.-C. TAI-CHUNG TSENG CHEN-HUA LIU Niu W.-F. Jeng J. CHUN-JEN LIU Lai M.-Y. PEI-JER CHEN JIA-HORNG KAO DING-SHINN CHEN |
公開日期: | 2011 | 出版社: | National Academy of Sciences | 卷: | 108 | 期: | 9 | 起(迄)頁: | 3719-3724 | 來源出版物: | Proceedings of the National Academy of Sciences of the United States of America | 摘要: | Asian patients with chronic hepatitis C (CHC) are known to have better virological responses to pegylated (Peg) IFN-based therapy than Western patients. Although IL28B gene polymorphisms may contribute to this difference, whether favorable hepatitis C virus (HCV) kinetics during treatment plays a role remains unclear. We enrolled 145 consecutive Taiwanese patients with CHC receiving Peg-IFN α-2a plus ribavirin for the study. Blood samples were taken more frequently at defined intervals in the first 3 d. Peg-IFN was administered at week 1. It was then administered weekly in combination with daily ribavirin for 24 or 48 wk. A mathematical model fitted to the observed HCV kinetics was constructed, which could interpret the transient HCV titer elevation after Peg-IFN treatment. The results demonstrated a comparable viral clearance rate (c = 3.45 ± 3.73) (day-1, mean ± SD) but lower daily viral production rate (P = 106-1012) in our patients than those reported previously in Western patients. Of 110 patients with a sustained virological response (SVR), 47 (43%) had a transient elevation of viral titer within 12 h (proportion of 12 h/3 d: 44% in non-SVR vs. 70% in SVR; P = 0.029). Among 91 patients with available rs8099917 data, patients with the TT genotype had an early surge of viral titer after therapy and a higher SVR and viral clearance rate than those with the GT genotype. In conclusion, Taiwanese patients with CHC receiving Peg-IFN plus ribavirin therapy have a lower daily viral production rate than Western patients, and the rs8099917 TT genotype may contribute to the increased viral clearance rate and better virological responses in these patients. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983723339&doi=10.1073%2fpnas.1100349108&partnerID=40&md5=0ecf80add85f22a97ddf3d021548867c https://scholars.lib.ntu.edu.tw/handle/123456789/568521 |
ISSN: | 0027-8424 | DOI: | 10.1073/pnas.1100349108 | SDG/關鍵字: | interleukin 28B; peginterferon alpha2a plus ribavirin; article; genotype; hepatitis C; human; major clinical study; mathematical model; priority journal; Taiwan; viral clearance; Hepatitis C virus |
顯示於: | 臨床醫學研究所 |
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