https://scholars.lib.ntu.edu.tw/handle/123456789/568574
標題: | Association of metabolic profiles with hepatic fibrosis in chronic hepatitis C patients with genotype 1 or 2 infection | 作者: | Hsu C.-S. CHEN-HUA LIU CHUN-JEN LIU SHIH-JER HSU CHI-LING CHEN HWANG, JUEY-JEN Lai M.-Y. PEI-JER CHEN DING-SHINN CHEN JIA-HORNG KAO |
公開日期: | 2010 | 出版社: | Blackwell Publishing | 卷: | 25 | 期: | 5 | 起(迄)頁: | 970-977 | 來源出版物: | Journal of Gastroenterology and Hepatology (Australia) | 摘要: | Background and Aims: Metabolic profiles are associated with severity of liver histology in chronic hepatitis C (CHC) infection. However, the influence of hepatitis C virus (HCV) genotypes, especially genotype 1 and 2, on the association between metabolic profiles and hepatic fibrosis remains unknown. Methods: We consecutively enrolled 528 CHC patients infected by HCV genotype 1 or 2, and used univariate and multivariate approaches to determine the influence of HCV genotype on the association of metabolic characteristics with severity of liver histology. Results: In univariate analysis, diabetes mellitus, obesity, higher grades of hepatic steatosis, homeostasis model assessment-insulin resistance index and alanine aminotransferase level, but lower serum total cholesterol and low-density lipoprotein level, were associated with advanced hepatic fibrosis. Advanced hepatic fibrosis was associated with an adjusted odds ratio of 13.72 (95% confidence interval, 2.15-87.7) for serum fasting blood glucose, 1.07 (1.01 to 1.13) for body mass index (BMI), and 0.03 (0.00-0.32) for total cholesterol level. Older age, lower serum total cholesterol level and more necro-inflammatory activity were associated with advanced hepatic fibrosis in both genotype 1 and 2 patients (P < 0.05). Advanced hepatic fibrosis was associated with an adjusted odds ratio of 31.18 (2.31-421.4) for fasting blood glucose level in genotype 1 infection, whereas 1.16 (1.05-1.28) for BMI in genotype 2 infection. Conclusions: Age, serum total cholesterol, and hepatic necro-inflammation have important associations with severity of hepatic fibrosis in CHC patients. Moreover, these associations are different between HCV genotype: the effects of fasting blood glucose level and BMI are increased on genotype 1 and genotype 2 patients, respectively. ? 2010 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77951701962&doi=10.1111%2fj.1440-1746.2009.06186.x&partnerID=40&md5=b0a3d6441bf87276c4824e401d5aa475 https://scholars.lib.ntu.edu.tw/handle/123456789/568574 |
ISSN: | 0815-9319 | DOI: | 10.1111/j.1440-1746.2009.06186.x | SDG/關鍵字: | alanine aminotransferase; cholesterol; glucose; insulin; low density lipoprotein; RNA; biological marker; cholesterol; glucose blood level; adult; alanine aminotransferase blood level; article; cholesterol blood level; demography; diabetes mellitus; fatty liver; female; genotype; glucose blood level; hepatitis C; Hepatitis C virus; human; insulin resistance; lipoprotein blood level; liver fibrosis; liver histology; major clinical study; male; obesity; priority journal; RNA extraction; Article; body mass; chronic hepatitis C; diet restriction; Hepatitis C virus genotype 1; Hepatitis C virus genotype 2; age; analysis; blood; body mass; chi square distribution; complication; cross-sectional study; genetics; Hepacivirus; Hepatitis C, Chronic; liver; liver cirrhosis; middle aged; pathology; prognosis; risk; risk assessment; risk factor; severity of illness index; statistical model; Taiwan; virology; Adult; Age Factors; Biological Markers; Blood Glucose; Body Mass Index; Chi-Square Distribution; Cholesterol; Cross-Sectional Studies; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Liver; Liver Cirrhosis; Logistic Models; Male; Middle Aged; Odds Ratio; Prognosis; Risk Assessment; Risk Factors; Severity of Illness Index; Taiwan |
顯示於: | 臨床醫學研究所 |
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