https://scholars.lib.ntu.edu.tw/handle/123456789/568609
標題: | Humoral and cellular immune responses to a hepatitis B vaccine booster 15-18 years after neonatal immunization | 作者: | CHUN-YI LU YEN-HSUAN NI BOR-LUEN CHIANG PEI-JER CHEN MEI-HWEI CHANG LUAN-YIN CHANG Su I.-J. Kuo H.-S. LI-MIN HUANG Chen D.-S. Lee C.-Y. |
公開日期: | 2008 | 出版社: | University of Chicago Press | 卷: | 197 | 期: | 10 | 起(迄)頁: | 1419-1426 | 來源出版物: | Journal of Infectious Diseases | 摘要: | Background. Whether hepatitis B (HB) vaccine-conferred immunity persists into adulthood is unknown. We aimed to investigate long-term HB immunity in adolescents. Methods. In 2004-2005, 6156 high school students (15-21 years old) who had been vaccinated with plasma-derived HB vaccine as infants were recruited for HB seromarker screening. The immune response to an HB vaccine booster was evaluated in 872 subjects who were seronegative. HB surface antibody (anti-HBs) titers and levels of HB surface antigen (HBsAg)-specific interferon (IFN)-γ- or interleukin (IL)-5-secreting peripheral blood mononuclear cells (PBMCs; measured by enzyme-linked immunospot assay) were determined 4 weeks later. Results. Although the vaccine remained highly efficacious in reducing the HBsAg positivity rate, 63.0% of the vaccinees had no protective anti-HBs. After the booster, anti-HBs remained undetectable in 28.7% (158/551) of the subjects who had received complete HB vaccination (4 doses) during infancy. We estimated that 10.1% of the total population had lost their HB vaccine- conferred booster response. HBsAg-specific IFN-γ- or IL-5-secreting PBMCs remained negative in 27.2% (25/92) of subjects after the booster. Conclusions. A notable proportion of fully vaccinated adolescents had lost immune memory conferred by a plasma-derived HB vaccine 15-18 years later. This decay of immune memory may raise concerns about the need for a booster vaccine for high-risk groups in the long run. ? 2008 by the Infectious Diseases Society of America. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984584335&doi=10.1086%2f587695&partnerID=40&md5=4fe76ac3f76fcb6237e097f8b30fb028 https://scholars.lib.ntu.edu.tw/handle/123456789/568609 |
ISSN: | 0022-1899 | DOI: | 10.1086/587695 | SDG/關鍵字: | gamma interferon; hepatitis B surface antibody; hepatitis B surface antigen; interleukin 5; recombinant hepatitis B vaccine; adolescent; adult; antibody response; antibody titer; article; cellular immunity; enzyme linked immunospot assay; hepatitis B; Hepatitis B virus; high school student; human; humoral immunity; peripheral blood mononuclear cell; priority journal; revaccination; statistical analysis |
顯示於: | 臨床醫學研究所 |
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