The genetic differences with whole genome linkage disequilibrium mapping between responder and non-responder in interferon-α and ribavirin combined therapy for chronic hepatitis C patients
Journal
International Journal of Immunogenetics
Journal Volume
35
Journal Issue
2
Pages
153-157
Date Issued
2008
Author(s)
Abstract
Interferon-α and ribavirin combined therapy has been a mainstream treatment for hepatitis C infection. The efficacy of this combined treatment is around 30% to 60%, and the factors affecting the responsiveness are still poorly defined. Our study is intended to investigate the genetic differences between responder and non-responder patients. The genome-wide linkage disequilibrium screening for loci associated with genetic difference between two patient groups was conducted by using 382 autosomal short tandem repeat (STR) markers involving 92 patients. We have identified 19 STR markers displaying different allele frequencies between the two patient groups. In addition, based on their genomic location and biological function, we selected the CD81 and IL15 genes to perform single nucleotide polymorphism genotyping. In conclusion, this study may provide a new approach for identifying the associated polymorphisms and the susceptible loci for interferon-α and ribavirin combined therapy in patients with chronic hepatitis C. ? 2008 The Authors.
SDGs
Other Subjects
alpha2a interferon; alpha2b interferon; ribavirin; article; combination chemotherapy; controlled study; drug response; gene frequency; gene mapping; genetic difference; genetic linkage; hepatitis C; human; major clinical study; priority journal; short tandem repeat; single nucleotide polymorphism; Antigens, CD; Antiviral Agents; Asian Continental Ancestry Group; Drug Resistance, Viral; Female; Genetic Markers; Genome, Human; Hepatitis C, Chronic; Humans; Interferon-alpha; Interleukin-15; Linkage Disequilibrium; Male; Microsatellite Repeats; Polymorphism, Single Nucleotide; Ribavirin; Taiwan; Hepatitis C virus
Type
journal article