https://scholars.lib.ntu.edu.tw/handle/123456789/568638
標題: | Somatic mutations at the trinucleotide repeats of androgen receptor gene in male hepatocellular carcinoma | 作者: | Shiou-Hwei Yeh Chiu C.-M. CHI-LING CHEN Lu S.-F. Hsu H.-C. DING-SHINN CHEN PEI-JER CHEN |
公開日期: | 2007 | 出版社: | Wiley-Liss Inc. | 卷: | 120 | 期: | 8 | 起(迄)頁: | 1610-1617 | 來源出版物: | International Journal of Cancer | 摘要: | Androgen and androgen receptor (AR) have long been implicated in liver carcinogenesis, especially for the male dominance feature. However, whether AR gene could occur in somatic mutations that might contribute to this process has not yet been studied. DNA sequencing and genotyping were conducted for detecting the genetic aberrations of AR gene in 257 primary hepatocellular carcinomas (HCCs) and also the dysplastic nodules (DN) from another 11 patients. Twenty-one AR somatic mutations causing amino acid changes were identified in HCC and even in the pre-cancerous DN. The missense somatic mutations of AR were rare in HCC (2 cases) but the trinucleotide repeat (TNR) changes, both at (CAG)n and (GGC)n, was a more common one (19 cases). Notably, all these mutations occurred in male patients and most TNR changes belonged to the contraction type (15 out of 19 cases, 78.9%), which has been reported to associate with increased AR transcriptional activity. Most samples with TNR changes did not show microsatellite instability, suggesting a different cause for these TNR mutations. Although no significant correlation was identified between AR mutations and the clinicopathologic parameters, we found the (CAG)n length significantly shorter in hepatitis B virus (HBV)(+) HCCs than in HBV(-) HCCs and the (GGC)n length significantly correlates with the overall survival. In conclusion, the mis-sense somatic mutations of AR were rare in HCC but the TNR change was a more common one, which exclusively occurred in males. Moreover, the length of TNR carried clinical significance in special HCC group. ? 2007 Wiley-Liss, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983721891&doi=10.1002%2fijc.22479&partnerID=40&md5=c2fef8596b320ac2fad9000e07646a0d https://scholars.lib.ntu.edu.tw/handle/123456789/568638 |
ISSN: | 0020-7136 | DOI: | 10.1002/ijc.22479 | SDG/關鍵字: | androgen; androgen receptor; adult; article; controlled study; DNA sequence; female; genetic transcription; genotype; Hepatitis B virus; Hepatitis C virus; human; human cell; human tissue; liver carcinogenesis; liver cell carcinoma; major clinical study; male; microsatellite instability; missense mutation; nucleotide sequence; precancer; priority journal; receptor gene; sex difference; somatic mutation; trinucleotide repeat |
顯示於: | 臨床醫學研究所 |
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