https://scholars.lib.ntu.edu.tw/handle/123456789/568646
標題: | Hepatitis B viral factors in HBeAg-negative carriers with persistently normal serum alanine aminotransferase levels | 作者: | Lin C.-L. Liao L.-Y. CHUN-JEN LIU MING-WHEI YU PEI-JER CHEN Lai M.-Y. DING-SHINN CHEN JIA-HORNG KAO |
公開日期: | 2007 | 出版社: | John Wiley and Sons Ltd | 卷: | 45 | 期: | 5 | 起(迄)頁: | 1193-1198 | 來源出版物: | Hepatology | 摘要: | Chronic hepatitis B patients with high-normal serum ALT (levels of 0.5-1 x upper limit of normal) are still at risk of liver disease progression. We thus investigated the correlation between serum ALT level and hepatitis B viral factors in HBeAg-negative carriers with persistently normal serum ALT level (PNALT). Baseline clinical and virological features of 414 HBeAg-negative carriers, including 176 (42.5%) with low-normal ALT (levels of less than 0.5 x upper limit of normal) and 238 (57.5%) with high-normal ALT, were compared. Compared with HBV carriers with low-normal ALT, those with high-normal ALT were older (41 vs. 37 years, P < 0.001) and had a greater frequency of serum HBV DNA level >104 copies/ml (63.4% vs. 47.5%, P < 0.001) as well as a higher prevalence of basal core promoter T1762/A1764 mutant (36.5% vs. 24.2%, P = 0.01). Multivariate analysis showed that factors associated with a high-normal serum ALT level included male sex [odds ratio (OR), 1.82; 95% confidence interval (CI), 1.10-3.01, P = 0.019], increasing age (OR, <30 years: 1, reference; 30-39 years: 2.43, 95% CI, 1.18-5.03, P = 0.016; 40-49 years: 4.22, 95% CI, 1.99-8.93, P < 0.001; ?50 years: 4.06, 95% CI, 1.69-9.78, P = 0.002) and serum HBV DNA level >104 copies/ml (OR, 1.83; 95% CI, 1.07-3.13, P = 0.027). Conclusion: HBeAg-negative patients with persistently normal ALT are not a homogenous group, and those with high-normal ALT share some of the characteristics that have been associated with adverse long-term outcomes. Copyright ? 2007 by the American Association for the Study of Liver Diseases. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984569437&doi=10.1002%2fhep.21585&partnerID=40&md5=8cb50b13d3657c484dbbf15ba8671f8a https://scholars.lib.ntu.edu.tw/handle/123456789/568646 |
ISSN: | 0270-9139 | DOI: | 10.1002/hep.21585 | SDG/關鍵字: | alanine aminotransferase; hepatitis B(e) antigen; virus DNA; adolescent; adult; aged; alanine aminotransferase blood level; article; controlled study; disease course; female; gene amplification; genotype; hepatitis B; heterozygote detection; human; major clinical study; male; multivariate analysis; priority journal; serology; virology |
顯示於: | 臨床醫學研究所 |
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