https://scholars.lib.ntu.edu.tw/handle/123456789/568655
標題: | Association of pre-S deletion mutant of hepatitis B virus with risk of hepatocellular carcinoma | 作者: | Lin C.-L. CHEN-HUA LIU Chen W. Huang W.-L. PEI-JER CHEN Lai M.-Y. DING-SHINN CHEN JIA-HORNG KAO |
公開日期: | 2007 | 出版社: | Blackwell Publishing | 卷: | 22 | 期: | 7 | 起(迄)頁: | 1098-1103 | 來源出版物: | Journal of Gastroenterology and Hepatology (Australia) | 摘要: | Background: Pre-S deletion mutant of hepatitis B virus (HBV) affects the expression of middle and small surface proteins, resulting in intracellular accumulation of large surface protein. The correlation between pre-S deletion mutant and risk of hepatocellular carcinoma (HCC) in hepatitis B virus carriers remains unclear. Methods: Using molecular assays, pre-S deletion mutant of HBV were determined in 266 patients with chronic HBV genotype B or C infection. They included 202 asymptomatic carriers and 64 HCC patients. Results: The overall prevalence of pre-S deletion mutant was 16.5%. Hepatocellular carcinoma (odds ratio [OR], 3.23; 95% confidence interval [CI], 1.23-8.48, P = 0.02) and genotype C (OR, 3.19; 95%CI, 1.54-6.62, P = 0.002) were independently associated with the presence of pre-S deletion mutant. The prevalence of pre-S deletion mutant was comparable between HCC patients with genotype B and C infection. Nevertheless, in asymptomatic carriers, patients with genotype C infection were significantly associated with the presence of pre-S deletion mutant compared to those with genotype B infection (20.8% vs 7.2%, P = 0.007). Compared with age- and genotype B-matched asymptomatic carriers, young HCC patients (<50 years of age) had a significantly higher frequency of pre-S deletion (3.4% vs 20%, P = 0.04). Conclusions: Pre-S deletion mutant is more frequent in HBV carriers with genotype C infection, and those with pre-S deletion mutant may be associated with the development of HCC, irrespective of HBV genotype. ? 2006 The Authors. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984550855&doi=10.1111%2fj.1440-1746.2006.04515.x&partnerID=40&md5=20208d8a32551c039826cefeed4566ba https://scholars.lib.ntu.edu.tw/handle/123456789/568655 |
ISSN: | 0815-9319 | DOI: | 10.1111/j.1440-1746.2006.04515.x | SDG/關鍵字: | virus protein; adolescent; adult; aged; article; cancer risk; confidence interval; controlled study; deletion mutant; female; genotype; Hepatitis B virus; human; liver cell carcinoma; major clinical study; male; prevalence; priority journal; risk assessment; virus carcinogenesis; virus carrier; virus mutant; virus mutation |
顯示於: | 臨床醫學研究所 |
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