https://scholars.lib.ntu.edu.tw/handle/123456789/568686
標題: | Post-translational modification of delta antigen of hepatitis D virus | 作者: | Huang W.-H. Chen C.-W. Wu H.-L. PEI-JER CHEN |
公開日期: | 2006 | 出版社: | Springer Verlag | 卷: | 307 | 起(迄)頁: | 91-112 | 來源出版物: | Current Topics in Microbiology and Immunology | 摘要: | The hepatitis delta virus (HDV) genome has only one open reading frame, which encodes the viral small delta antigen. After RNA editing, the same open reading frame is extended 19 amino acids at the carboxyl terminus and encodes the large delta antigen. These two viral proteins escort the HDV genome through different cellular compartments for the complicated phases of replication, transcription and, eventually, the formation of progeny virions. To orchestrate these events, the delta antigens have to take distinct cues to traffic to the right compartments and make correct molecular contacts. In eukaryotes, post-translational modification (PTM) is a major mechanism of dictating the multiple functions of a single protein. Multiple PTMs, including phosphorylation, isoprenylation, acetylation, and methylation, have been identified on hepatitis delta antigens. In this chapter we review these PTMs and discuss their functions in regulating and coordinating the life cycle of HDV. ? Springer-Verlag 2006. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33748102101&doi=10.1007%2f3-540-29802-9_5&partnerID=40&md5=53412fdcedade74c181dcf1f84faae7c https://scholars.lib.ntu.edu.tw/handle/123456789/568686 |
ISSN: | 0070-217X | DOI: | 10.1007/3-540-29802-9_5 | SDG/關鍵字: | arginine; casein kinase II; cysteine; hepatitis delta antigen; lysine; methyltransferase; protein farnesyltransferase; protein kinase C; protein kinase R; protein p300; serine; threonine; virus enzyme; virus RNA; hepatitis delta antigen; acetylation; amino acid sequence; carboxy terminal sequence; eukaryote; genome analysis; Hepatitis delta virus; human; life cycle; nonhuman; open reading frame; priority journal; progeny; protein function; protein methylation; protein phosphorylation; protein processing; regulatory mechanism; review; RNA editing; virion; virus genome; biosynthesis; methylation; molecular genetics; phosphorylation; virus replication; Eukaryota; Hepatitis delta virus; Acetylation; Amino Acid Sequence; Hepatitis delta Antigens; Methylation; Molecular Sequence Data; Phosphorylation; Protein Isoprenylation; Protein Processing, Post-Translational; Virus Replication |
顯示於: | 臨床醫學研究所 |
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