https://scholars.lib.ntu.edu.tw/handle/123456789/568703
標題: | Basal core-promoter mutant of hepatitis B virus and progression of liver disease in hepatitis B e antigen-negative chronic hepatitis B | 作者: | Lin C.-L. Liao L.-Y. Wang C.-S. PEI-JER CHEN Lai M.-Y. DING-SHINN CHEN JIA-HORNG KAO |
公開日期: | 2005 | 出版社: | Blackwell Publishing Ltd | 卷: | 25 | 期: | 3 | 起(迄)頁: | 564-570 | 來源出版物: | Liver International | 摘要: | Background/Aims: The long term outcomes in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B are distinct from those in HBeAg-positive chronic hepatitis. However, the molecular virological factors that contribute to the progression of liver disease in this special clinical setting remain largely unknown. We thus investigated the association of hepatitis B virus (HBV) genotypes as well as precore/basal core-promoter mutations with the clinical and virological characteristics of patients with HBeAg-negative chronic hepatitis B in Taiwan. Methods: HBV genotypes and sequences of precore and basal core-promoter regions of the HBV genome were determined in 174 HBeAg-negative chronic HBV infection patients including 62 inactive carriers and 112 with different stages of liver disease. Results: HBV carriers with older age (>50 years) (odds ratio, 9.09; 95% confidence interval (CI), 3.22-25, P<0.001) and basal core-promoter mutant of HBV (odds ratio, 4.12; 95% CI, 1.41-12.03, P = 0.01) were associated with the development of liver cirrhosis and hepatocellular carcinoma (HCC). The gender-related risk factors associated with the development of liver cirrhosis and HCC were further analyzed, and basal core-promoter mutant was only associated with the development of liver cirrhosis and HCC in male carriers (odds ratio, 4.35; 95% CI, 1.30-14.52, P = 0.02). Conclusions: The risk of development of liver cirrhosis and HCC is significantly increased in patients with advanced age as well as with basal core-promoter mutant of HBV. In addition, basal core-promoter mutant might contribute to the gender difference of the progression of liver disease in HBeAg-negative chronic hepatitis B in Taiwan. ? Blackwell Munksgaard 2005. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984549645&doi=10.1111%2fj.1478-3231.2005.01041.x&partnerID=40&md5=12f52148a4af21c29039917341cc3940 https://scholars.lib.ntu.edu.tw/handle/123456789/568703 |
ISSN: | 1478-3223 | DOI: | 10.1111/j.1478-3231.2005.01041.x | SDG/關鍵字: | hepatitis B(e) antigen; adolescent; adult; age distribution; aged; article; chronic liver disease; confidence interval; controlled study; disease course; female; gene amplification; genotype; hepatitis B; Hepatitis B virus; human; liver cell carcinoma; liver cirrhosis; major clinical study; male; molecular genetics; mutational analysis; prognosis; promoter region; risk factor; sequence analysis; sex difference; Taiwan; viral genetics; virus mutant |
顯示於: | 臨床醫學研究所 |
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