https://scholars.lib.ntu.edu.tw/handle/123456789/568756
標題: | Clinical aspects and outcomes of volunteer blood donors testing positive for hepatitis-C virus infection in Taiwan: A prospective study | 作者: | CHUN-JEN LIU PEI-JER CHEN Shau W.-Y. JIA-HORNG KAO Lai M.-Y. DING-SHINN CHEN |
公開日期: | 2003 | 出版社: | Blackwell Publishing Ltd | 卷: | 23 | 期: | 3 | 起(迄)頁: | 148-155 | 來源出版物: | Liver International | 摘要: | Background/Aim: The natural history of hepatitis-C virus (HCV) infection has been explored in volunteer blood donors, but not yet in hepatitis-B endemic areas. Whether previous or concurrent hepatitis-B virus (HBV) infection influences the natural history of HCV infection remains unknown. Thus, we followed the anti-HCV-positive blood donors who had past or concurrent HBV infection in Taiwan. Methods: From 1992 to 1993, 1588 anti-HCV reactive volunteer blood donors were referred to us from the Taipei Blood Center and 879 (55%) repeatedly reactive for anti-HCV were enrolled. Two hundred and forty-three donors (HCV RNA seropositive rate 49% by polymerase chain reaction (PCR)) received regular follow-ups (mean period: 4.9 years) with their liver disease status determined mainly by clinical and biochemical parameters, serum alpha-fetoprotein level and imaging studies. Hepatitis-C virus genotype and occult HBV infection were determined by PCR-based assays. Results: Of the initial 879 subjects, 250 (28%) had chronic hepatitis, nine (1%) had liver cirrhosis (LC) and two (0.2%) had hepatocellular carcinoma (HCC) already. In the 243 regularly followed donors, 30% had repeatedly normal serum alanine aminotransferase (ALT) and 70% had more than once elevated ALT. Cirrhosis developed in four (1.6%; follow-up period range: 2-6 years) and HCC in two (0.8%; follow-up period: 3 and 4 years, respectively). Distribution of HCV genotype and hepatitis-B surface antigen (HBsAg) did not differ between those with and those without elevation of ALT. Of the 15 donors with LC and/or HCC, only 1(7%) was positive for both HBsAg and HBV DNA and the other 14 were negative for both HBsAg and serum HBV DNA. Conclusions: Incidentally detected hepatitis-C was progressive in a small proportion of anti-HCV-positive volunteer blood donors in Taiwan. Occult HBV infection played a minimal role in the development of LC in this donor population. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984575691&doi=10.1034%2fj.1600-0676.2003.00820.x&partnerID=40&md5=9150fbacd145601e0789103869d1c014 https://scholars.lib.ntu.edu.tw/handle/123456789/568756 |
ISSN: | 1478-3223 | DOI: | 10.1034/j.1600-0676.2003.00820.x | SDG/關鍵字: | alanine aminotransferase; alpha fetoprotein; hepatitis B surface antigen; virus antibody; virus DNA; virus RNA; adolescent; adult; alanine aminotransferase blood level; article; biochemistry; blood donor; chronic hepatitis; clinical study; controlled study; diagnostic imaging; disease activity; female; follow up; genotype; hepatitis B; Hepatitis B virus; hepatitis C; Hepatitis C virus; human; immunoreactivity; liver carcinogenesis; liver cell carcinoma; liver cirrhosis; major clinical study; male; nonhuman; outcomes research; polymerase chain reaction; prospective study; protein blood level; school child; serodiagnosis; superinfection; Taiwan; virus pathogenesis; volunteer |
顯示於: | 臨床醫學研究所 |
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