https://scholars.lib.ntu.edu.tw/handle/123456789/568803
標題: | Interspousal transmission of TT virus: Low efficiency and lack of apparent risk factors | 作者: | CHUN-JEN LIU JIA-HORNG KAO Chen W. Tsai R.-J. PEI-JER CHEN Lai M.-Y. DING-SHINN CHEN |
公開日期: | 2000 | 出版社: | Blackwell Publishing | 卷: | 15 | 期: | 11 | 起(迄)頁: | 1287-1291 | 來源出版物: | Journal of Gastroenterology and Hepatology (Australia) | 摘要: | Background: The TT virus (TTV) is a newly identified human DNA virus and little is known about its non-parenteral transmission. The aim of the present study was to explore the prevalence of TTV infection in spouses of index cases and the related risk factors. Methods: Serum TTV-DNA was studied in spouses of 41 subjects with TT viremia. For couples in which both husband and wife had TT viremia, nucleotide sequences of the open reading frame-1 region were analyzed by phylogenetic tree constructions. Results: Three (7%) of 41 spouses were positive for TTV-DNA. No differences were noted between index patients with seropositive spouses and those without seropositive spouses with regard to clinical characteristics, including parenteral risk factors and exposure duration. Nucleotide sequence comparison and phylogenetic tree analysis of the viral genome in three TTV-infected couples revealed the isolates to be closely related in two, with a homology of 97 and 98%, respectively. Conclusions: These results suggest that interspousal transmission of TTV does occur; however, the efficiency of transmission is low compared with hepatitis C virus and GB virus-C. There are no apparent risk factors for transmission between spouses and further studies are needed to clarify other modes of non-parenteral transmission. (C) 2000 Blackwell Science Asia Pty Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984578716&doi=10.1046%2fj.1440-1746.2000.02339.x&partnerID=40&md5=18f852a55a3a07e7020ec7a5af251333 https://scholars.lib.ntu.edu.tw/handle/123456789/568803 |
ISSN: | 0815-9319 | DOI: | 10.1046/j.1440-1746.2000.02339.x | SDG/關鍵字: | article; clinical article; disease transmission; female; human; infection risk; male; priority journal; risk assessment; seroprevalence; Torque teno virus; viremia; virus infection |
顯示於: | 臨床醫學研究所 |
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