https://scholars.lib.ntu.edu.tw/handle/123456789/568805
標題: | TT virus infection in patients with chronic hepatitis B or C: Influence on clinical, histological and virological features | 作者: | JIA-HORNG KAO Chen W. PEI-JER CHEN Lai M.-Y. DING-SHINN CHEN |
公開日期: | 2000 | 出版社: | Wiley-Liss Inc. | 卷: | 60 | 期: | 4 | 起(迄)頁: | 387-392 | 來源出版物: | Journal of Medical Virology | 摘要: | Concomitant infection with TT virus and hepatitis B virus (HBV) or hepatitis C virus (HCV) is common. However, the effect of TTV infection on chronic hepatitis B or C is unknown. The prevalence of TTV infection, the effect of TTV infection on the clinical, histological and virological features of patients with chronic hepatitis B or C, and the influence of TTV infection on the HCV response to interferon alfa therapy were studied. A total of 100 asymptomatic hepatitis B surface antigen carriers, 220 patients with HBV-related chronic liver diseases, and 110 patients with chronic hepatitis C treated with interferon alfa (3 million units subcutaneously three times a week for 24 weeks) were enrolled. Serum HCV RNA and serum TTV DNA were detected by the polymerase chain reaction (PCR). Serum HBV DNA and serum HCV RNA level were quantified by branched DNA assays. Infection with TTV was detected in 21.5% of HBV carriers and 37% of HCV carriers. TTV infection had little effect on the clinicopathological course of chronic HBV infection. In chronic hepatitis C, clinical features, histological severity, serum HCV RNA levels, and the response to interferon alfa therapy did not differ between those with and without TTV infection. The loss of serum TTV DNA did not correlate with the biochemical response as did in the loss of serum HCV RNA. In conclusion, TTV infection is found frequently in patients with chronic hepatitis B or C in Taiwan; however, coinfection with TTV does not affect the clinicopathological course of chronic hepatitis B or C and the response to interferon alfa therapy. (C) 2000 Wiley-Liss, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984552664&doi=10.1002%2f%28SICI%291096-9071%28200004%2960%3a4%3c387%3a%3aAID-JMV4%3e3.0.CO%3b2-Z&partnerID=40&md5=83c92ab22eea6e53072515fdaa5646f4 https://scholars.lib.ntu.edu.tw/handle/123456789/568805 |
ISSN: | 0146-6615 | DOI: | 10.1002/(SICI)1096-9071(200004)60:4<387 | SDG/關鍵字: | alpha interferon; virus DNA; virus RNA; adult; article; chronic liver disease; disease course; female; genotype; hepatitis B; Hepatitis B virus; hepatitis C; Hepatitis C virus; human; immunotherapy; liver histology; major clinical study; male; polymerase chain reaction; superinfection; Taiwan; Torque teno virus; virus carrier; virus detection; virus load; DNA viruses; Hepatitis B virus; Hepatitis C virus; RNA viruses; TT virus |
顯示於: | 臨床醫學研究所 |
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