https://scholars.lib.ntu.edu.tw/handle/123456789/568806
標題: | Low incidence of hepatitis C virus transmission between spouses: A prospective study | 作者: | JIA-HORNG KAO CHUN-JEN LIU PEI-JER CHEN Chen W. Lai M.-Y. DING-SHINN CHEN |
公開日期: | 2000 | 出版社: | Blackwell Publishing | 卷: | 15 | 期: | 4 | 起(迄)頁: | 391-395 | 來源出版物: | Journal of Gastroenterology and Hepatology (Australia) | 摘要: | Background: Interspousal transmission of hepatitis C virus (HCV) has been documented; however, the annual risk of interspousal transmission remains unclear. Methods: A long-term prospective study to define the risk of interspousal transmission of HCV was conducted. One hundred and twelve index patients with chronic hepatitis C and their anti-HCV seronegative spouses were enrolled. Results: The mean follow-up period was 45.9 months. Antibodies to HCV (anti-HCV) and HCV-RNA were tested for in each seronegative spouse every year. Seroconversion of anti-HCV occurred in only one spouse, 2 years after enrolment, with a concomitant acute hepatitis. This subject and his spouse were infected with HCV genotype 1b. Nucleotide sequence comparison of the hypervariable region of their HCV genomes showed a homology of 98%. Further phylogenetic analysis suggested that they had virtually the same isolate. Accordingly, the annual risk of interspousal transmission of HCV infection was 0.23% per year. Conclusions: These findings suggest a low incidence of interspousal transmission of HCV; however, the risk may be cumulative and such couples should be educated to avoid HCV infection from their spouses. (C) 2000 Blackwell Science Asia Pty Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984549255&doi=10.1046%2fj.1440-1746.2000.02165.x&partnerID=40&md5=7a1f09d0bc9df82956996c5594432dec https://scholars.lib.ntu.edu.tw/handle/123456789/568806 |
ISSN: | 0815-9319 | DOI: | 10.1046/j.1440-1746.2000.02165.x | SDG/關鍵字: | hepatitis C antibody; virus RNA; adult; antibody detection; article; clinical trial; female; follow up; genotype; hepatitis C; Hepatitis C virus; human; infection risk; major clinical study; male; nucleotide sequence; phylogeny; priority journal; sequence homology; seroconversion; spouse; virus genome; virus transmission |
顯示於: | 臨床醫學研究所 |
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