https://scholars.lib.ntu.edu.tw/handle/123456789/568843
標題: | Molecular biology of hepatitis D virus: Research and potential for application | 作者: | PEI-JER CHEN Wu H.-L. Wang C.-J. Chia J.-H. DING-SHINN CHEN |
關鍵字: | DNA vaccine; Hepatitis D virus; Protein modification; Ribozyme; Vaccine; Yeast | 公開日期: | 1997 | 出版社: | Blackwell Publishing | 卷: | 12 | 期: | 9-10 | 起(迄)頁: | S188-S192 | 來源出版物: | Journal of Gastroenterology and Hepatology (Australia) | 摘要: | Superinfection by hepatitis D virus (HDV) leads to acute hepatitis and causes progression to liver cirrhosis in a significant proportion of hepatitis B surface antigen (HBsAg) carriers. Current regimens (interferon) to treat hepatitis D patients has only transient but no lasting effects. New approaches are, therefore, warranted. Recently, several laboratory studies have discovered interesting properties of HDV that may become targets for antiviral chemicals. Vital replication requires the small hepatitis delta antigen (s-HDAg). The s-HDAg is a nuclear phosphoprotein. There is evidence indicating that phosphorylation is important for HDV replication. A second step of replication requires HDV-RNA self-cleavage and self-ligation. Interestingly, one group of antibiotics, the aminoglycosides, exerts strong suppression effects on HDV ribozyme activities. In the following stage of viral assembly, two post-translational modifications, namely isoprenylation of large HDAg and glycosylation of HBsAg are involved. Agents capable of blocking the two modifications should reduce vital production. These four possible targets are reviewed. For prevention, effective vaccines are not yet available. Two novel approaches are discussed. The first demonstrates the immunogenicity of a nucleic acid vaccine in mice. The second approach assembled an empty HDV particle in yeast. Advances on such laboratory investigations may provide new methods for the control of hepatitis D in the future. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984569930&doi=10.1111%2fj.1440-1746.1997.tb00500.x&partnerID=40&md5=d20a863b71d589d7429762254abbf203 https://scholars.lib.ntu.edu.tw/handle/123456789/568843 |
ISSN: | 0815-9319 | DOI: | 10.1111/j.1440-1746.1997.tb00500.x | SDG/關鍵字: | aminoglycoside antibiotic agent; antibiotic g 418; cefoperazone; DNA vaccine; gentamicin; hepatitis B surface antigen; hepatitis delta antigen; interferon; kanamycin; neomycin; netilmicin; phosphoprotein; ribozyme; streptomycin; tobramycin; virus RNA; conference paper; delta agent hepatitis; Hepatitis delta virus; human; isoprenylation; liver cirrhosis; medical research; molecular biology; nonhuman; priority journal; protein glycosylation; protein modification; superinfection; virus assembly; virus carrier; virus replication |
顯示於: | 臨床醫學研究所 |
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