https://scholars.lib.ntu.edu.tw/handle/123456789/568910
標題: | Hepatitis B vims in the colostra of HBeAg-positive carrier mothers | 作者: | HO-HSIUNG LIN HONG-YUAN HSU MEI-HWEI CHANG PEI-JER CHEN DING-SHINN CHEN |
公開日期: | 1993 | 卷: | 17 | 期: | 2 | 起(迄)頁: | 207-210 | 來源出版物: | Journal of Pediatric Gastroenterology and Nutrition | 摘要: | To investigate the amount of hepatitis B virus (HBV) in colostra of hepatitis B e antigen (HBeAg)-positive carrier mothers and the relationship of HBV amount between colostrum and maternal blood, 50 HBeAg-positive carrier mothers were recruited and studied for hepatitis B surface antigen (HBsAg) titer, HBeAg titer, and HBV-DNA concentration in their sera and colostra. According to the presence or absence of serai HBV-DNA determined by dot hybridization, these 50 HBeAg-positive carrier mothers could be divided into two groups: Group 1 (n = 28, HBV-DNA <0.04 ng/ml), and group 2 (n = 22, HBV-DNA 5=0.04 ng/ml). The co-lostral HBsAg and HBeAg titers were both significantly higher in group 2 than in group 1. In addition, both co-lostral HBsAg and HBeAg titers had positive correlation with each corresponding maternal blood. Although the colostral HBV-DNA was undetectable by dot hybridization, all were positive by polymerase chain reaction with Southern blot hybridization. Because HBV-DNA can be detected in all HBeAg-positive carrier mother’s milk, it reinforces the necessity of hepatitis B vaccination for the neonates born to these carrier mothers, particularly in countries with a high carrier rate. ? 1993 Raven Press, Ltd., New York. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027305593&doi=10.1097%2f00005176-199308000-00014&partnerID=40&md5=7009e09e389f13f43e509e16b8ba97ca https://scholars.lib.ntu.edu.tw/handle/123456789/568910 |
ISSN: | 0277-2116 | DOI: | 10.1097/00005176-199308000-00014 | SDG/關鍵字: | hepatitis B surface antigen; hepatitis B(e) antigen; virus DNA; article; breast milk; colostrum; controlled study; disease carrier; female; hepatitis B; Hepatitis B virus; human; major clinical study; priority journal; vertical transmission; virus transmission; Base Sequence; Carrier State; Colostrum; DNA Primers; DNA, Viral; Electrophoresis, Agar Gel; Female; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B Virus; Human; Molecular Sequence Data; Mothers; Nucleic Acid Hybridization; Polymerase Chain Reaction; Support, Non-U.S. Gov't; DNA viruses; Hepatitis B virus |
顯示於: | 臨床醫學研究所 |
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