Expression of AKR1B10 as an independent marker for poor prognosis in human oral squamous cell carcinoma
Journal
Head and Neck
Journal Volume
39
Journal Issue
7
Pages
1327-1332
Date Issued
2017
Author(s)
Abstract
Background: Aldo-keto reductase family 1 member B10 (AKR1B10) is implicated in xenobiotic detoxification and has disparate functions in tumorigenesis that are dependent on the cell types. The purpose of this study was to investigate the clinicopathological significance of AKR1B10 as a prognostic marker for oral squamous cell carcinomas (OSCCs). Methods: AKR1B10 protein expression was analyzed by immunohistochemistry in 77 patients with OSCC. Results: The AKR1B10 labeling score for OSCCs (1.16 ± 1.14) was significantly higher than that for normal oral mucosa (0.10 ± 0.23; p <.0001). High expression of AKR1B10 significantly correlated with large tumor size (p =.041), advanced TNM classification (p =.037), and patient's areca quid chewing habit (p =.025). Multivariate analysis revealed that high AKR1B10 labeling score >1.16 (hazard ratio, 3.647; p =.001) significantly correlated with mortality. Conclusion: AKR1B10 overexpression is an independent poor prognostic biomarker for OSCC. AKR1B10 inhibitors may be promising in clinical trials against OSCC. ? 2017 Wiley Periodicals, Inc. Head Neck 39: 1327–1332, 2017. ? 2017 Wiley Periodicals, Inc.
SDGs
Other Subjects
aldo keto reductase family 1 member b10 protein; protein; unclassified drug; AKR1B10 protein, human; aldehyde reductase; tumor marker; adult; areca quid; Article; cancer classification; cancer growth; cancer mortality; cancer prognosis; cancer size; controlled study; disease marker; female; gene overexpression; human; human cell; human tissue; immunohistochemistry; major clinical study; male; mastication; mouth squamous cell carcinoma; priority journal; aged; cohort analysis; disease free survival; factual database; gene expression regulation; genetics; Kaplan Meier method; middle aged; mortality; mouth tumor; multivariate analysis; needle biopsy; pathology; prognosis; proportional hazards model; retrospective study; risk assessment; squamous cell carcinoma; survival analysis; Taiwan; Adult; Aged; Aldehyde Reductase; Biomarkers, Tumor; Biopsy, Needle; Carcinoma, Squamous Cell; Cohort Studies; Databases, Factual; Disease-Free Survival; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; Mouth Neoplasms; Multivariate Analysis; Prognosis; Proportional Hazards Models; Retrospective Studies; Risk Assessment; Survival Analysis; Taiwan
Publisher
John Wiley and Sons Inc.
Type
journal article