Significant association of SRC protein expression with the progression, recurrence, and prognosis of oral squamous cell carcinoma in Taiwan
Journal
Head and Neck
Journal Volume
34
Journal Issue
9
Pages
1340-1345
Date Issued
2012
Author(s)
Cheng S.-L.
Huang Y.-L.
Abstract
Background Src protein overexpression correlates with progression and prognosis of a variety of human cancers. Methods This study used immunohistochemistry to examine the expression of Src protein in 93 specimens of oral squamous cell carcinoma (OSCC). Results We found a significant association of high expression of Src protein (labeling indices >50%) with larger tumor size (p =.017), positive lymph node metastasis (p =.030), more advanced clinical stages (p =.007), and recurrence (p <.001) of OSCC. High expression of Src protein was identified as an independent unfavorable prognosis factor by multivariate Cox regression analysis. The Kaplan-Meier curve showed that patients with OSCC with high expression of Src protein had a significantly poorer cumulative survival than those with low expression of Src protein (log-rank test, p =.00267). Conclusion The expression of Src protein is significantly associated with the progression, recurrence, and prognosis of OSCCs in Taiwan. ? 2011 Wiley Periodicals, Inc.
Other Subjects
membrane protein; Src protein; tumor marker; unclassified drug; advanced cancer; article; cancer growth; cancer recurrence; cancer size; cancer survival; controlled study; disease association; disease marker; female; human; human tissue; lymph node metastasis; major clinical study; male; mouth squamous cell carcinoma; priority journal; prognosis; protein expression; Taiwan; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Disease Progression; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; Mouth Neoplasms; Prognosis; Proteomics; Recurrence; src-Family Kinases; Taiwan; Tumor Markers, Biological
Type
journal article