https://scholars.lib.ntu.edu.tw/handle/123456789/569164
標題: | Significant association of SRC protein expression with the progression, recurrence, and prognosis of oral squamous cell carcinoma in Taiwan | 作者: | SHIH-JUNG CHENG SANG-HENG KOK JANG-JAER LEE YEN-PING KUO Cheng S.-L. Huang Y.-L. HSIN-MING CHEN HAO-HUENG CHANG CHUN-PIN CHIANG |
公開日期: | 2012 | 卷: | 34 | 期: | 9 | 起(迄)頁: | 1340-1345 | 來源出版物: | Head and Neck | 摘要: | Background Src protein overexpression correlates with progression and prognosis of a variety of human cancers. Methods This study used immunohistochemistry to examine the expression of Src protein in 93 specimens of oral squamous cell carcinoma (OSCC). Results We found a significant association of high expression of Src protein (labeling indices >50%) with larger tumor size (p =.017), positive lymph node metastasis (p =.030), more advanced clinical stages (p =.007), and recurrence (p <.001) of OSCC. High expression of Src protein was identified as an independent unfavorable prognosis factor by multivariate Cox regression analysis. The Kaplan-Meier curve showed that patients with OSCC with high expression of Src protein had a significantly poorer cumulative survival than those with low expression of Src protein (log-rank test, p =.00267). Conclusion The expression of Src protein is significantly associated with the progression, recurrence, and prognosis of OSCCs in Taiwan. ? 2011 Wiley Periodicals, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84864981889&doi=10.1002%2fhed.21923&partnerID=40&md5=2e1886b4640e9995e718d3648f754b7a https://scholars.lib.ntu.edu.tw/handle/123456789/569164 |
ISSN: | 1043-3074 | DOI: | 10.1002/hed.21923 | SDG/關鍵字: | membrane protein; Src protein; tumor marker; unclassified drug; advanced cancer; article; cancer growth; cancer recurrence; cancer size; cancer survival; controlled study; disease association; disease marker; female; human; human tissue; lymph node metastasis; major clinical study; male; mouth squamous cell carcinoma; priority journal; prognosis; protein expression; Taiwan; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Disease Progression; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; Mouth Neoplasms; Prognosis; Proteomics; Recurrence; src-Family Kinases; Taiwan; Tumor Markers, Biological |
顯示於: | 牙醫學系 |
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