https://scholars.lib.ntu.edu.tw/handle/123456789/569174
標題: | Increased prevalence of interleukin-17-producing CD4 + tumor infiltrating lymphocytes in human oral squamous cell carcinoma | 作者: | JANG-JAER LEE Chang Y.-L. Lai W.-L. JENG-YUH KO YEN-PING KUO CHUN-PIN CHIANG Azuma M. Chen C.-W. JEAN-SAN CHIA |
公開日期: | 2011 | 卷: | 33 | 期: | 9 | 起(迄)頁: | 1301-1308 | 來源出版物: | Head and Neck | 摘要: | Background. T helper 17 (Th17) and regulatory T cells share plasticity in the expression of interleukin (IL)-17 and forkhead box P3 (FOXP3), but their mutual presence in human diseases is unclear. Methods. IL-17 and FOXP3 were analyzed by immunohistostaining and flow cytometry. The cytokine milieu was analyzed by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). Results. Oral squamous cell carcinoma expresses high levels of IL-1β, IL-6, and transforming growth factor (TGF)-β. A unique subset of FOXP3 + IL-17-producing CD4 + T cells was consistently identified in tumor-infiltrating lymphocytes from advanced stages of cancer, but not in the circulation, at a frequency of 0.5% to 5.5 % of total CD4 + T and positively correlated with the frequency of IL-17 +FOXP3 - T cells. The IL-17 +FOXP3 + T cells express CCR6 and suppress the proliferation of autologous CD4 + CD25 - responder T-cells in vitro. Conclusions. The prevalence of IL-17-producing FOXP3 + CD4 + tumor infiltrating lymphocytes is increased in oral squamous cell carcinoma. ? 2010 Wiley Periodicals, Inc. Head Neck, 2010 Copyright ? 2010 Wiley Periodicals, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-80051765765&doi=10.1002%2fhed.21607&partnerID=40&md5=882d9cc6fe0ea57896dca1c73e056e0f https://scholars.lib.ntu.edu.tw/handle/123456789/569174 |
ISSN: | 1043-3074 | DOI: | 10.1002/hed.21607 | SDG/關鍵字: | chemokine receptor CCR6; interleukin 17; interleukin 1beta; interleukin 6; transcription factor FOXP3; transforming growth factor beta; adult; aged; article; cancer staging; CD25+ T lymphocyte; CD4+ T lymphocyte; clinical article; controlled study; female; flow cytometry; gingiva; human; human cell; human tissue; immunohistochemistry; lymphocyte proliferation; male; mouth carcinoma; prevalence; priority journal; protein analysis; reverse transcription polymerase chain reaction; squamous cell carcinoma; tumor associated leukocyte; Adult; Aged; Carcinoma, Squamous Cell; Case-Control Studies; CD4-Positive T-Lymphocytes; Female; Flow Cytometry; Forkhead Transcription Factors; Humans; Immunohistochemistry; Interleukin-17; Interleukin-1beta; Interleukin-6; Lymphocytes, Tumor-Infiltrating; Male; Middle Aged; Mouth Neoplasms; Prevalence; Receptors, CCR6; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta |
顯示於: | 牙醫學系 |
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