https://scholars.lib.ntu.edu.tw/handle/123456789/569186
標題: | Expression of BCL10 is significantly associated with the progression and prognosis of oral squamous cell carcinomas in Taiwan | 作者: | HAO-HUENG CHANG YEN-PING KUO SHIH-JUNG CHENG CHUN-PIN CHIANG |
公開日期: | 2009 | 卷: | 45 | 期: | 7 | 起(迄)頁: | 589-593 | 來源出版物: | Oral Oncology | 摘要: | This study used an immunohistochemical technique to examine the expression of BCL10 in 93 specimens of oral squamous cell carcinoma (OSCC) and 21 specimens of normal oral mucosa (NOM). We found a significant correlation between the higher mean BCL10 labeling index (LI) and OSCCs at the tongue, with larger tumor size, with positive lymph node metastasis, with more advanced clinical stages, or with recurrence (all p-values = 0.000). Positive lymph node metastasis (p = 0.044) and BCL10 LI > 50% (p = 0.037) were identified as independent unfavorable prognosis factors by multivariate analyses with Cox regression model. The Kaplan-Meier curve showed that OSCC patients with a BCL10 LI > 50% had a significantly poorer cumulative survival than those with a BCL10 LI < 50% (log-rank test, p < 0.00001). We conclude that the BCL10 LI in OSCC samples can predict the progression of OSCCs and the survival of OSCC patients. ? 2008 Elsevier Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-67549127813&doi=10.1016%2fj.oraloncology.2008.08.003&partnerID=40&md5=bac2e4261340452ddff0eb1ab0b2ad66 https://scholars.lib.ntu.edu.tw/handle/123456789/569186 |
ISSN: | 1368-8375 | DOI: | 10.1016/j.oraloncology.2008.08.003 | SDG/關鍵字: | protein bcl 10; adult; aged; article; cancer growth; cancer recurrence; cancer size; cancer staging; cancer survival; controlled study; correlation analysis; female; human; human tissue; immunohistochemistry; lymph node metastasis; major clinical study; male; mouth carcinoma; mouth mucosa; priority journal; prognosis; protein expression; squamous cell carcinoma; Taiwan; Adaptor Proteins, Signal Transducing; Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Case-Control Studies; Disease Progression; Female; Humans; Kaplan-Meier Estimate; Lymphatic Metastasis; Male; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Prognosis; Taiwan; Tumor Markers, Biological; Young Adult |
顯示於: | 牙醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。