|Title:||Expression of hypoxia-inducible factor-1α is significantly associated with the progression and prognosis of oral squamous cell carcinomas in Taiwan||Authors:||Lin P.-Y.
|Issue Date:||2008||Journal Volume:||37||Journal Issue:||1||Start page/Pages:||18-25||Source:||Journal of Oral Pathology and Medicine||Abstract:||
Background: Overexpression of hypoxia-inducible factor-1α (HIF-1α) has been found to be significantly associated with the tumor invasion, lymph node metastasis, clinical stage, and prognosis of a variety of human cancers. Methods: This study examined the expression of HIF-1α in 57 specimens of oral squamous cell carcinoma (OSCC), 41 specimens of oral epithelial dysplasia (OED, 12 mild, 17 moderate, and 12 severe OED cases), and 14 specimens of normal oral mucosa (NOM) by immunohistochemistry. Results: We found that the mean nuclear HIF-1α labeling indices (LIs) increased significantly from NOM (9 ± 6%) through mild OED (25 ± 18%), moderate OED (41 ± 27%), and severe OED (42 ± 22%) to OSCC samples (55 ± 23%, P < 0.001). A significant correlation was found between the higher mean nuclear HIF-1α LI and OSCCs with larger tumor size (P < 0.001), regional lymph node metastasis (P < 0.001), or more advanced clinical stages (P < 0.001). Only larger tumor size (P = 0.002) and nuclear HIF-1α LI ? 60% (P = 0.048) were identified as independent unfavorable prognosis factor by multivariate analyses with Cox regression model. Kaplan-Meier curve showed that OSCC patients with a nuclear HIF-1α LI ? 60% had a significantly poorer cumulative survival than those with a nuclear HIF-1α LI < 60% (log-rank test, P = 0.022). Conclusions: We conclude that the expression of HIF-1α is an early event in oral carcinogenesis. The nuclear HIF-1α LI in OSCC samples can predict the progression of OSCCs and the survival of OSCC patients. ? 2007 The Authors.
|ISSN:||0904-2512||DOI:||10.1111/j.1600-0714.2007.00571.x||SDG/Keyword:||hypoxia inducible factor 1alpha; adult; aged; article; cancer growth; cancer survival; controlled study; correlation analysis; disease association; disease severity; female; gene expression; human; human tissue; immunohistochemistry; Kaplan Meier method; log rank test; male; mouth carcinoma; multivariate analysis; priority journal; prognosis; proportional hazards model; squamous cell carcinoma; Taiwan; tumor volume; Adult; Aged; Alcohol Drinking; Analysis of Variance; Carcinoma, Squamous Cell; Disease Progression; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoenzyme Techniques; Kaplan-Meiers Estimate; Male; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Precancerous Conditions; Prognosis; Proportional Hazards Models; Smoking; Taiwan; Tumor Markers, Biological
|Appears in Collections:||牙醫學系|
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