TGF-β1 stimulates cyclooxygenase-2 expression and PGE2 production of human dental pulp cells: Role of ALK5/Smad2 and MEK/ERK signal transduction pathways
Journal
Journal of the Formosan Medical Association
Journal Volume
116
Journal Issue
10
Pages
748-754
Date Issued
2017
Author(s)
Lin P.-S.
Cheng R.-H.
Chang M.-C.
Huang W.-L.
Yeung S.-Y.
Chang Y.-C.
Abstract
BACKGROUND/PURPOSES: production in dental pulp cells. METHODS: levels. RT-PCR and western blot were used to determined COX-2 mRNA and protein, respectively. RESULTS: production of dental pulp cells. Under the pretreatment of SB431542, the stimulatory effect of TGF-β1 on COX-2 level of pulp cells was inhibited. Similarly, U0126 also partly inhibited the TGF-β1-induced COX-2 expression. CONCLUSION: level of cultured pulp cells. The effect of TGF-β1 on COX-2 protein expression was associated with ALK5/Smad2/3 and MEK/ERK pathways. These events are important in the early inflammation, repair and regeneration of dental pulp in response to injury.
SDGs
Publisher
Elsevier B.V.
Type
journal article