https://scholars.lib.ntu.edu.tw/handle/123456789/570016
標題: | Risk of subsequent attention-deficit/hyperactivity disorder among children and adolescents with amalgam restorations: A nationwide longitudinal study | 作者: | Lin P.-Y. Wang J. YU-CHIH CHIANG Lai C.-Y. Chang H.-J. Chi L.-Y. |
關鍵字: | ADHD; amalgam; survival analysis; Taiwan national health insurance research database | 公開日期: | 2018 | 出版社: | Blackwell Munksgaard | 卷: | 46 | 期: | 1 | 起(迄)頁: | 47-53 | 來源出版物: | Community Dentistry and Oral Epidemiology | 摘要: | Objectives: Dental amalgam has been used as a common restorative material since the 1800s, but concerns have been raised regarding its purported neuropsychological effects due to the neurotoxicity of mercury. In this study, a nationwide population-based database was employed to investigate the association of dental amalgam restoration with the risk of attention-deficit/hyperactivity disorder (ADHD). Methods: After matching, 88 068 young people with at least one tooth restoration during 2002-2010 and no ADHD history before 2001 were selected and then collected the further information until the end of 2011. Cox proportional hazard models were employed to estimate the possible effect of amalgam restorations on the risk of ADHD during the period of 2002-2011. Subgroup analyses were performed according to age, sex and number of amalgam restorations. Results: In total, 2073 people (2.4%) received an ADHD diagnosis during the study period, yielding an incidence rate of 32.4 per 100 000 person-years. Those who had 6 or more amalgam restorations had a higher risk of future ADHD in the unadjusted Cox proportional hazard regression model (hazard ratio=1.20, 95% confidence interval [CI]=1.04-1.38, P=.015) than those who had received composite resin or glass ionomer restorations. However, after adjustment for potential confounding factors, the result was found to be confounded by age. Conclusions: The univariate analysis results showed that those who had 6 or more amalgam restorations had a 20% higher risk of future ADHD; however, the association disappeared after the model was adjusted for age. Despite this study analysing a larger sample than those analysed in previous studies, no association was observed between young patients’ having received amalgam restorations and a future ADHD diagnosis. Further research aimed at evaluating the association between dental amalgam and other subsequent neuropsychological effects is warranted, especially for people who are vulnerable to mercury exposure. ? 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85027140804&doi=10.1111%2fcdoe.12327&partnerID=40&md5=a18702a9e7e0e258a5e7dae5ea6e90ad https://scholars.lib.ntu.edu.tw/handle/123456789/570016 |
ISSN: | 0301-5661 | DOI: | 10.1111/cdoe.12327 | SDG/關鍵字: | dental amalgam; adolescent; age; attention deficit disorder; child; dental restoration; female; human; longitudinal study; male; preschool child; procedures; proportional hazards model; risk factor; sex factor; Adolescent; Age Factors; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Dental Amalgam; Dental Restoration, Permanent; Female; Humans; Longitudinal Studies; Male; Proportional Hazards Models; Risk Factors; Sex Factors |
顯示於: | 臨床牙醫學研究所 |
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