https://scholars.lib.ntu.edu.tw/handle/123456789/570206
標題: | Anemia, hematinic deficiencies, and gastric parietal cell antibody positivity in atrophic glossitis patients with or without hyperhomocysteinemia | 作者: | CHUN-PIN CHIANG Wu Y.-C. JULIA YU-FONG CHANG YI-PING WANG Wu Y.-H. ANDY SUN |
公開日期: | 2020 | 出版社: | NLM (Medline) | 卷: | 119 | 期: | 1 | 起(迄)頁: | 544-552 | 來源出版物: | Journal of the Formosan Medical Association = Taiwan yi zhi | 摘要: | BACKGROUND/PURPOSE: Our previous study found that 127 of 1064 atrophic glossitis (AG) patients have hyperhomocysteinemia. This study assessed whether the AG patients with hyperhomocysteinemia had significantly higher frequencies of anemia, hematinic deficiencies, and serum gastric parietal cell antibody (GPCA) positivity than AG patients without hyperhomocysteinemia or healthy control subjects. METHODS: The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 127 AG patients with hyperhomocysteinemia, 937 AG patients without hyperhomocysteinemia, and 532 healthy control subjects were measured and compared. RESULTS: We found that 127 AG patients with hyperhomocysteinemia had significantly higher frequencies of blood Hb and serum iron, vitamin B12, and folic acid deficiencies and serum GPCA positivity than 532 healthy control subjects (all P-values?0.001) and significantly higher frequencies of blood Hb and serum vitamin B12 and folic acid deficiencies and serum GPCA positivity than 937 AG patients without hyperhomocysteinemia (all P-values?0.001). Moreover, 127 AG patients with hyperhomocysteinemia had significantly higher frequencies of macrocytic anemia and significantly lower frequencies of normocytic anemia than 937 AG patients without hyperhomocysteinemia (both P-values?0.001). Pernicious anemia (22 cases) was found only?in?AG patients with hyperhomocysteinemia but not in AG patients without hyperhomocysteinemia. CONCLUSION: AG patients with hyperhomocysteinemia had significantly higher frequencies of anemia, serum iron, vitamin B12, and folic acid deficiencies, and serum GPCA positivity than healthy control subjects and significantly higher frequencies of anemia, serum vitamin B12 and folic acid deficiencies, and serum GPCA positivity than AG patients without hyperhomocysteinemia. Copyright ? 2019 Formosan Medical Association. Published by Elsevier B.V. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077403990&doi=10.1016%2fj.jfma.2019.08.002&partnerID=40&md5=7938f1aea8a5ef715dc9de54313f281b https://scholars.lib.ntu.edu.tw/handle/123456789/570206 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2019.08.002 | SDG/關鍵字: | autoantibody; cyanocobalamin; folic acid; hemoglobin; iron; adult; aged; anemia; atrophy; blood; case control study; erythrocyte count; female; glossitis; human; hyperhomocysteinemia; immunology; male; mean corpuscular volume; middle aged; stomach parietal cell; Taiwan; very elderly; young adult; Adult; Aged; Aged, 80 and over; Anemia; Atrophy; Autoantibodies; Case-Control Studies; Erythrocyte Count; Erythrocyte Indices; Female; Folic Acid; Glossitis; Hemoglobins; Humans; Hyperhomocysteinemia; Iron; Male; Middle Aged; Parietal Cells, Gastric; Taiwan; Vitamin B 12; Young Adult |
顯示於: | 臨床牙醫學研究所 |
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