https://scholars.lib.ntu.edu.tw/handle/123456789/570208
標題: | Does serum gastric parietal cell antibody titer have influence on anemia and vitamin B12 deficiency in atrophic glossitis patients? | 作者: | CHUN-PIN CHIANG Wu Y.-H. JULIA YU-FONG CHANG YI-PING WANG Wu Y.-C. ANDY SUN |
公開日期: | 2020 | 出版社: | Elsevier B.V. | 卷: | 119 | 期: | 1P2 | 起(迄)頁: | 377-383 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: Our previous study found 284 gastric parietal cell antibody (GPCA)-positive atrophic glossitis (AG) patients (so-called GPCA+AG patients in this study) in a group of 1064 AG patients. This study evaluated whether high-titer (GPCA titer ? 160) GPCA+AG patients had greater frequencies of anemia, vitamin B12 deficiency, macrocytosis, and hyperhomocysteinemia than low-titer (GPCA titer < 160) GPCA+AG patients. Methods: Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 117 high-titer GPCA+AG patients, 167 low-titer GPCA+AG patients, and 532 healthy control subjects were measured and compared. Results: We found that 12.0%, 29.1%, 23.1%, 16.2%, 1.7%, and 23.1% of 117 high-titer GPCA+AG patients and 5.4%, 17.4%, 17.4%, 7.2%, 1.2%, and 14.4% of 167 low-titer GPCA+AG patients were diagnosed as having macrocytosis, blood hemoglobin, iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia, respectively. Moreover, both 117 high-titer and 167 low-titer GPCA+AG patients had significantly greater frequencies of macrocytosis, blood hemoglobin, serum iron and vitamin B12 deficiencies, and hyperhomocysteinemia than 532 healthy control subjects (all P-values < 0.05). In addition, 117 high-titer GPCA+AG patients also had greater frequencies of anemia (P = 0.029, statistically significant), serum vitamin B12 deficiency (P = 0.027, statistically significant), macrocytosis (P = 0.075, marginal significance), and hyperhomocysteinemia (P = 0.085, marginal significance) than 167 low-titer GPCA+AG patients. Conclusion: For GPCA+AG patients, high-titer GPCA+AG patients have greater frequencies of anemia, serum vitamin B12 deficiency, macrocytosis, and hyperhomocysteinemia than low-titer GPCA+AG patients. ? 2019 Formosan Medical Association |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85068179233&doi=10.1016%2fj.jfma.2019.06.009&partnerID=40&md5=054b83a725aea7bd1e03015b333ead24 https://scholars.lib.ntu.edu.tw/handle/123456789/570208 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2019.06.009 | SDG/關鍵字: | cyanocobalamin; folic acid; hemoglobin; homocysteine; iron; parietal cell antibody; autoantibody; cyanocobalamin; folic acid; hemoglobin; homocysteine; iron; adult; aged; anemia; antibody titer; Article; B12 deficiency; blood cell count; controlled study; female; folic acid blood level; glossitis; hemoglobin blood level; human; human cell; hyperhomocysteinemia; iron blood level; major clinical study; male; mean corpuscular volume; megalocytosis; vitamin blood level; atrophy; B12 deficiency; blood; case control study; complication; glossitis; hyperhomocysteinemia; immunology; macrocytic anemia; middle aged; pathology; stomach parietal cell; tongue; very elderly; Adult; Aged; Aged, 80 and over; Anemia, Macrocytic; Atrophy; Autoantibodies; Case-Control Studies; Erythrocyte Indices; Female; Folic Acid; Glossitis; Hemoglobins; Homocysteine; Humans; Hyperhomocysteinemia; Iron; Male; Middle Aged; Parietal Cells, Gastric; Tongue; Vitamin B 12; Vitamin B 12 Deficiency |
顯示於: | 臨床牙醫學研究所 |
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