https://scholars.lib.ntu.edu.tw/handle/123456789/570211
標題: | Hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in atrophic glossitis patients with macrocytosis | 作者: | CHUN-PIN CHIANG Wu Y.-H. JULIA YU-FONG CHANG YI-PING WANG Wu Y.-C. ANDY SUN |
公開日期: | 2019 | 出版社: | Elsevier B.V. | 卷: | 118 | 期: | 11 | 起(迄)頁: | 1515-1521 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: Macrocytosis is defined as having the mean corpuscular volume (MCV) ≧ 100 fL. This study evaluated whether 41 atrophic glossitis (AG) patients with macrocytosis had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than 532 healthy control subjects or 1064 AG patients. Methods: Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 41 AG patients with macrocytosis, 1064 AG patients, and 532 healthy control subjects were measured and compared. Results: We found that 73.2%, 22.0%, 73.2%, 4.9%, 80.5%, and 56.1% of 41 AG patients with macrocytosis were diagnosed as having blood hemoglobin, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Moreover, 41 AG patients with macrocytosis had significantly higher frequencies of blood hemoglobin and serum vitamin B12 deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 532 healthy control subjects or 1064 AG patients (all P-values < 0.001). In addition, 41 AG patients with macrocytosis also had significantly higher frequencies of serum iron and folic acid deficiencies than 532 healthy control subjects (both P-values < 0.001). Pernicious anemia was found in 22 AG patients with macrocytosis. Conclusion: There are significantly higher frequencies of anemia and serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity in AG patients with macrocytosis than in healthy control subjects. AG patients with macrocytosis also have significantly higher frequencies of blood hemoglobin and serum vitamin B12 deficiencies, hyperhomocysteinemia, and serum GPCA positivity than AG patients. ? 2019 Formosan Medical Association |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85068932373&doi=10.1016%2fj.jfma.2019.07.001&partnerID=40&md5=8f004cb3ba56a4e31387cb2e13b3fced https://scholars.lib.ntu.edu.tw/handle/123456789/570211 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2019.07.001 | SDG/關鍵字: | cyanocobalamin; folic acid; hemoglobin; homocysteine; iron; parietal cell antibody; antianemic agent; autoantibody; cyanocobalamin; folic acid; hemoglobin; homocysteine; iron; adult; aged; anemia; antibody blood level; Article; atrophic glossitis; B12 deficiency; blood cell count; controlled study; female; folic acid blood level; folic acid deficiency; glossitis; hemoglobin blood level; human; hyperhomocysteinemia; iron blood level; macrocytic anemia; major clinical study; male; mean corpuscular volume; megalocytosis; pernicious anemia; vitamin blood level; anemia; atrophy; blood; case control study; complication; glossitis; hematologic disease; hyperhomocysteinemia; immunology; middle aged; pathology; stomach parietal cell; tongue; very elderly; young adult; Adult; Aged; Aged, 80 and over; Anemia; Anemia, Macrocytic; Atrophy; Autoantibodies; Case-Control Studies; Erythrocyte Indices; Female; Folic Acid; Glossitis; Hematinics; Hematologic Diseases; Hemoglobins; Homocysteine; Humans; Hyperhomocysteinemia; Iron; Male; Middle Aged; Parietal Cells, Gastric; Tongue; Vitamin B 12; Young Adult |
顯示於: | 臨床牙醫學研究所 |
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