https://scholars.lib.ntu.edu.tw/handle/123456789/570217
標題: | Anemia, hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative atrophic glossitis patients | 作者: | CHUN-PIN CHIANG JULIA YU-FONG CHANG YI-PING WANG Wu Y.-H. Wu Y.-C. Sun A. |
公開日期: | 2019 | 出版社: | Elsevier B.V. | 卷: | 118 | 期: | 2 | 起(迄)頁: | 565-571 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: Approximately 27% of atrophic glossitis (AG) patients have the serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether the serum GPCA or AG itself was a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA-positive AG (GPCA + AG) and GPCA-negative AG (GPCA ? AG) patients. Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 284 GPCA + AG, 780 GPCA ? AG patients, and 532 healthy control subjects. Results: Both 284 GPCA + AG and 780 GPCA ? AG patients had significantly higher frequencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia than 532 healthy control subjects. Moreover, 284 GPCA + AG patients had significantly higher frequencies of macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia than 780 GPCA ? AG patients. Sixty-three (22.2%) of 284 GPCA + AG patients and 139 (17.8%) of 780 GPCA ? AG patients had anemia. The normocytic anemia (42.9%), pernicious anemia (34.9%), and iron deficiency anemia (15.9%) were the three most common types of anemia in the 63 anemic GPCA + AG patients. Moreover, the normocytic anemia (64.8%), iron deficiency anemia (14.4%), and thalassemia trait-induced anemia (13.7%) were the three most common types of anemia in 139 anemic GPCA ? AG patients. Conclusion: The disease of AG itself is a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in both GPCA + AG and GPCA ? AG patients. The serum GPCA also plays a significant role in causing macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia in GPCA + AG patients. ? 2018 Formosan Medical Association |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85058633737&doi=10.1016%2fj.jfma.2018.12.005&partnerID=40&md5=69b2129a198aa7974ef14e3e8d06420d https://scholars.lib.ntu.edu.tw/handle/123456789/570217 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2018.12.005 | SDG/關鍵字: | cyanocobalamin; folic acid; hemoglobin; homocysteine; iron; parietal cell antibody; autoantibody; cyanocobalamin; folic acid; hemoglobin; iron; adult; aged; anemia; antibody blood level; Article; controlled study; cyanocobalamin deficiency; erythrocyte; female; folic acid blood level; folic acid deficiency; glossitis; hemoglobin blood level; human; hyperhomocysteinemia; iron blood level; iron deficiency; iron deficiency anemia; macrocytic anemia; major clinical study; male; mean corpuscular volume; megalocytosis; microcytic anemia; microcytosis; pernicious anemia; thalassemia; very elderly; young adult; anemia; atrophy; blood; case control study; erythrocyte count; glossitis; hyperhomocysteinemia; immunology; middle aged; stomach parietal cell; Taiwan; Adult; Aged; Aged, 80 and over; Anemia; Atrophy; Autoantibodies; Case-Control Studies; Erythrocyte Count; Erythrocyte Indices; Female; Folic Acid; Glossitis; Hemoglobins; Humans; Hyperhomocysteinemia; Iron; Male; Middle Aged; Parietal Cells, Gastric; Taiwan; Vitamin B 12; Young Adult |
顯示於: | 臨床牙醫學研究所 |
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