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  5. Significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in atrophic glossitis patients
 
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Significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in atrophic glossitis patients

Journal
Journal of the Formosan Medical Association
Journal Volume
117
Journal Issue
12
Pages
1065-1071
Date Issued
2018
Author(s)
CHUN-PIN CHIANG  
JULIA YU-FONG CHANG  
YI-PING WANG  
Wu Y.-C.
Wu Y.-H.
Sun A.
DOI
10.1016/j.jfma.2018.07.016
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050911480&doi=10.1016%2fj.jfma.2018.07.016&partnerID=40&md5=2ef6bb049834036d04ea025eb2b9674d
https://scholars.lib.ntu.edu.tw/handle/123456789/570221
Abstract
Background/Purpose: Atrophic glossitis (AG) patients are prone to have anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity. This study evaluated whether 1064 AG patients had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 532 healthy control subjects. Methods: The complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and serum GPCA levels in 1064 AG patients and 532 age- and sex-matched healthy control subjects were measured and compared. Results: We found that 7.4%, 3.9%, 19.0%, 16.9%, 5.3%, 2.3%, 11.9%, and 26.7% of 1064 AG patients were diagnosed as having microcytosis, macrocytosis, hemoglobin, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Moreover, 1064 AG patients had significantly higher frequencies of microcytosis, macrocytosis, hemoglobin, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 532 healthy control subjects (all P-values < 0.005). Of the 202 anemic AG patients, 22 had pernicious anemia, eight had macrocytic anemia rather than pernicious anemia, 117 had normocytic anemia, 30 had iron deficiency anemia, and 21 had thalassemia trait-induced anemia, and four had microcytic anemia rather than iron deficiency anemia and thalassemia trait-induced anemia. Conclusion: There are significantly higher frequencies of anemia, serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity in AG patients than in healthy control subjects. The normocytic anemia and iron deficiency anemia are the two most common types of anemia in our 1064 AG patients. ? 2018
SDGs

[SDGs]SDG3

Other Subjects
cyanocobalamin; folic acid; homocysteine; parietal cell antibody; autoantibody; cyanocobalamin; folic acid; hemoglobin; iron; adult; aged; anemia; antibody blood level; Article; atrophic glossitis; blood cell count; burning sensation; controlled study; cyanocobalamin deficiency; female; folic acid deficiency; glossitis; hematinic deficiency; hemoglobin blood level; human; hyperhomocysteinemia; incidence; iron blood level; iron deficiency; iron deficiency anemia; macrocytic anemia; major clinical study; male; measurement; megalocytosis; microcytic anemia; microcytosis; paresthesia; pernicious anemia; taste disorder; thalassemia; varicosis; xerostomia; anemia; atrophy; blood; case control study; erythrocyte count; glossitis; hyperhomocysteinemia; immunology; mean corpuscular volume; middle aged; stomach parietal cell; Taiwan; very elderly; young adult; Adult; Aged; Aged, 80 and over; Anemia; Atrophy; Autoantibodies; Case-Control Studies; Erythrocyte Count; Erythrocyte Indices; Female; Folic Acid; Glossitis; Hemoglobins; Humans; Hyperhomocysteinemia; Iron; Male; Middle Aged; Parietal Cells, Gastric; Taiwan; Vitamin B 12; Young Adult
Publisher
Elsevier B.V.
Type
journal article

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