Gastric parietal cell and thyroid autoantibodies in Behcet's disease patients with or without atrophic glossitis
Journal
Journal of the Formosan Medical Association
Journal Volume
117
Journal Issue
8
Pages
691-696
Date Issued
2018
Author(s)
Abstract
Background/Purpose: Behcet's disease (BD) patients should have recurrent aphthous stomatitis (RAS) but they may or may not have atrophic glossitis (AG). This study mainly assessed the frequencies of serum gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) positivities in 30 AG-positive RAS/BD (AG+RAS/BD) and 33 AG-negative RAS/BD (AG?RAS/BD) patients. Methods: The frequencies of serum GPCA, TGA, and TMA positivities in 30 AG+RAS/BD patients, 33 AG?RAS/BD patients, and 126 healthy control subjects were calculated and compared. Results: We found that 20.0%, 30.0%, and 26.7% of 30 AG+RAS/BD patients, 9.1%, 12.1%, and 15.2% of 33 AG?RAS/BD patients, and 1.6%, 2.4%, and 2.4% of 126 healthy control subject had the presence of GPCA, TGA, and TMA in their sera, respectively. The 30 AG+RAS/BD patients had significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects (all P-values < 0.001). The 33 AG?RAS/BD patients had a higher frequency of serum TGA positivity (P = 0.051, marginal significance) and a significantly higher frequency of serum TMA positivity (P = 0.011) than healthy control subjects. Although the 30 AG+RAS/BD patients had higher frequencies of serum GPCA, TGA, and TMA positivities than the 33 AG?RAS/BD patients, the differences were not significant. Conclusion: AG+RAS/BD patients do have significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects. This finding indicates that the concomitant presence of AG may result in significantly elevated frequencies of serum GPCA, TGA, and TMA positivities in BD patients. ? 2018
SDGs
Other Subjects
parietal cell antibody; thyroglobulin antibody; thyroid antibody; thyroid microsomal antibody; unclassified drug; autoantibody; thyroglobulin; adult; aged; antibody blood level; Article; atrophic glossitis; Behcet disease; controlled study; female; glossitis; human; major clinical study; male; stomach parietal cell; adolescent; Behcet disease; blood; case control study; complication; glossitis; immunology; middle aged; stomach parietal cell; Taiwan; thyroid gland; very elderly; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Autoantibodies; Behcet Syndrome; Case-Control Studies; Female; Glossitis; Humans; Male; Middle Aged; Parietal Cells, Gastric; Taiwan; Thyroglobulin; Thyroid Gland; Young Adult
Publisher
Elsevier B.V.
Type
journal article