https://scholars.lib.ntu.edu.tw/handle/123456789/570228
標題: | Gastric parietal cell and thyroid autoantibodies in Behcet's disease patients with or without atrophic glossitis | 作者: | Wu Y.-H. JULIA YU-FONG CHANG YI-PING WANG Wu Y.-C. HSIN-MING CHEN Sun A. |
公開日期: | 2018 | 出版社: | Elsevier B.V. | 卷: | 117 | 期: | 8 | 起(迄)頁: | 691-696 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: Behcet's disease (BD) patients should have recurrent aphthous stomatitis (RAS) but they may or may not have atrophic glossitis (AG). This study mainly assessed the frequencies of serum gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) positivities in 30 AG-positive RAS/BD (AG+RAS/BD) and 33 AG-negative RAS/BD (AG?RAS/BD) patients. Methods: The frequencies of serum GPCA, TGA, and TMA positivities in 30 AG+RAS/BD patients, 33 AG?RAS/BD patients, and 126 healthy control subjects were calculated and compared. Results: We found that 20.0%, 30.0%, and 26.7% of 30 AG+RAS/BD patients, 9.1%, 12.1%, and 15.2% of 33 AG?RAS/BD patients, and 1.6%, 2.4%, and 2.4% of 126 healthy control subject had the presence of GPCA, TGA, and TMA in their sera, respectively. The 30 AG+RAS/BD patients had significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects (all P-values < 0.001). The 33 AG?RAS/BD patients had a higher frequency of serum TGA positivity (P = 0.051, marginal significance) and a significantly higher frequency of serum TMA positivity (P = 0.011) than healthy control subjects. Although the 30 AG+RAS/BD patients had higher frequencies of serum GPCA, TGA, and TMA positivities than the 33 AG?RAS/BD patients, the differences were not significant. Conclusion: AG+RAS/BD patients do have significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects. This finding indicates that the concomitant presence of AG may result in significantly elevated frequencies of serum GPCA, TGA, and TMA positivities in BD patients. ? 2018 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045571582&doi=10.1016%2fj.jfma.2018.03.015&partnerID=40&md5=c82fa1586812c74e8fa7fb5ff727e630 https://scholars.lib.ntu.edu.tw/handle/123456789/570228 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2018.03.015 | SDG/關鍵字: | parietal cell antibody; thyroglobulin antibody; thyroid antibody; thyroid microsomal antibody; unclassified drug; autoantibody; thyroglobulin; adult; aged; antibody blood level; Article; atrophic glossitis; Behcet disease; controlled study; female; glossitis; human; major clinical study; male; stomach parietal cell; adolescent; Behcet disease; blood; case control study; complication; glossitis; immunology; middle aged; stomach parietal cell; Taiwan; thyroid gland; very elderly; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Autoantibodies; Behcet Syndrome; Case-Control Studies; Female; Glossitis; Humans; Male; Middle Aged; Parietal Cells, Gastric; Taiwan; Thyroglobulin; Thyroid Gland; Young Adult |
顯示於: | 臨床牙醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。