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  3. School of Dentistry / 牙醫專業學院
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  5. Hemoglobin, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia in Behcet's disease patients with atrophic glossitis
 
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Hemoglobin, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia in Behcet's disease patients with atrophic glossitis

Journal
Journal of the Formosan Medical Association
Journal Volume
117
Journal Issue
7
Pages
559-565
Date Issued
2018
Author(s)
Wu Y.-H.
JULIA YU-FONG CHANG  
YI-PING WANG  
Wu Y.-C.
HSIN-MING CHEN  
Sun A.
DOI
10.1016/j.jfma.2018.03.005
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85044104905&doi=10.1016%2fj.jfma.2018.03.005&partnerID=40&md5=67af8c680d466edae19534a6c88c1c5a
https://scholars.lib.ntu.edu.tw/handle/123456789/570229
Abstract
Background/Purpose: Behcet's disease (BD) patients should have recurrent aphthous stomatitis (RAS) but they may or may not have atrophic glossitis (AG). This study mainly assessed whether 30 AG-positive RAS/BD (AG+RAS/BD) patients had significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia than 33 AG-negative RAS/BD (AG?RAS/BD) patients or 126 age- and sex-matched healthy control subjects. Methods: The blood hemoglobin, iron, vitamin B12, folic acid, and homocysteine concentrations were measured and compared among 30 AG+RAS/BD patients, 33 AG?RAS/BD patients, and 126 healthy control subjects. Results: We found that 43.3%, 33.3%, 13.3%, 6.7%, and 20.0% of 30 AG+RAS/BD patients and 18.2%, 36.4%, 0%, 6.1%, and 9.1% of 33 AG?RAS/BD patients had hemoglobin, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia, respectively. Moreover, 30 AG+RAS/BD patients had significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia than healthy control subjects (all P-values < 0.05), and had a higher frequency of hemoglobin deficiency (P = 0.058, marginal significance) and a significantly higher frequency of vitamin B12 deficiency (P = 0.046) than 33 AG?RAS/BD patients. In addition, the 33 AG?RAS/BD patients had significantly higher frequencies of hemoglobin and iron deficiencies than healthy control subjects (both P-values < 0.001). Conclusion: We conclude that AG+RAS/BD patients do have significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia than healthy control subjects and have significantly higher frequencies of hemoglobin and vitamin B12 deficiencies than AG?RAS/BD patients. ? 2018
SDGs

[SDGs]SDG3

Other Subjects
cyanocobalamin; folic acid; hemoglobin; homocysteine; iron; cyanocobalamin; folic acid; hemoglobin; homocysteine; iron; adult; aged; amino acid blood level; aphthous stomatitis; Article; Behcet disease; controlled study; cyanocobalamin deficiency; female; folic acid blood level; folic acid deficiency; frequency; glossitis; hemoglobin blood level; hemoglobinopathy; human; hyperhomocysteinemia; iron blood level; iron deficiency; iron deficiency anemia; macrocytic anemia; major clinical study; male; pernicious anemia; vitamin blood level; adolescent; aphthous stomatitis; atrophy; Behcet disease; blood; case control study; complication; cyanocobalamin deficiency; deficiency; folic acid deficiency; glossitis; hyperhomocysteinemia; middle aged; Taiwan; very elderly; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Atrophy; Behcet Syndrome; Case-Control Studies; Female; Folic Acid; Folic Acid Deficiency; Glossitis; Hemoglobins; Homocysteine; Humans; Hyperhomocysteinemia; Iron; Male; Middle Aged; Stomatitis, Aphthous; Taiwan; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult
Publisher
Elsevier B.V.
Type
journal article

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