Langerhans cell counts in oral epithelial dysplasia and their correlation to clinicopathological parameters
Journal
Journal of the Formosan Medical Association
Journal Volume
116
Journal Issue
6
Pages
457-463
Date Issued
2017
Author(s)
Abstract
Background/Purpose Langerhans cells (LCs) are antigen presenting cells. This study assessed the LC counts in oral epithelial dysplasia (OED) and their correlation to clinicopathological parameters. Methods This study examined the LC counts in the epithelia and subepithelial connective tissues of 58 patients with OED (21 mild, 18 moderate, and 19 severe OED lesions) and 10 specimens of normal oral mucosa (NOM) by anti-S-100 protein immunostaining. Results We found that the mean LC counts in the epithelia or subepithelial connective tissues increased significantly from NOM samples through mild and moderate OED to severe OED samples. In addition, a significant correlation was found between higher mean LC counts in the dysplastic epithelia of OED samples and OED lesions with thicker epithelial layers (p?
SDGs
Other Subjects
adult; aged; Article; cell count; connective tissue; controlled study; dysplasia; female; human; human cell; human tissue; immunohistochemistry; Langerhans cell; major clinical study; male; mouth disease; mouth mucosa; oral epithelial dysplasia; case control study; cell count; cell transformation; epithelium; Langerhans cell; middle aged; pathology; precancer; very elderly; young adult; Adult; Aged; Aged, 80 and over; Case-Control Studies; Cell Count; Cell Transformation, Neoplastic; Epithelium; Female; Humans; Langerhans Cells; Male; Middle Aged; Mouth Mucosa; Precancerous Conditions; Young Adult
Publisher
Elsevier B.V.
Type
journal article