Increased expression of MCM5 is significantly associated with aggressive progression and poor prognosis of oral squamous cell carcinoma
Journal
Journal of Oral Pathology and Medicine
Journal Volume
43
Journal Issue
5
Pages
344-349
Date Issued
2014
Author(s)
Abstract
Background: Overexpression of MCM5 protein has been found to be significantly associated with the progression and prognosis of several human cancers. Methods: This study used immunohistochemistry to examine the expression of MCM5 protein in 97 specimens of oral squamous cell carcinomas (OSCC), 80 specimens of oral epithelial dysplasia (OED, including 31 mild, 29 moderate, and 20 severe OED samples), and 20 specimens of normal oral mucosa (NOM). Results: We found that the mean nuclear MCM5 labeling indices (LIs) increased significantly from NOM (15?±?6%), through mild (25?±?10%), moderate (34?±?9%), and severe OED (43?±?12%), to OSCC samples (61?±?16%, P?
SDGs
Other Subjects
cell cycle protein; MCM5 protein, human; adult; aged; cancer grading; cancer staging; cell nucleus; chemistry; disease course; DNA replication; female; gene expression regulation; human; immunohistochemistry; lymph node metastasis; male; middle aged; mouth mucosa; mouth tumor; precancer; prognosis; secondary; squamous cell carcinoma; survival rate; tongue tumor; tumor invasion; very elderly; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Cell Cycle Proteins; Cell Nucleus; Disease Progression; DNA Replication; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Lymphatic Metastasis; Male; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Staging; Precancerous Conditions; Prognosis; Survival Rate; Tongue Neoplasms
Publisher
Blackwell Publishing Ltd
Type
journal article