https://scholars.lib.ntu.edu.tw/handle/123456789/570610
標題: | First Asian population study of stereotactic body radiation therapy for ventricular arrhythmias | 作者: | LI-TING HO JENNY LING-YU CHEN Chan, Hsing-Min Huang, Yu-Cheng MAO-YUAN SU SUNG-HSIN KUO YEUN-CHUNG CHANG JIUNN-LEE LIN WEN-JONE CHEN WEN-JENG LEE LIAN-YU LIN |
公開日期: | 14-五月-2021 | 卷: | 11 | 期: | 1 | 來源出版物: | Scientific reports | 摘要: | We report the first Asian series on stereotactic body radiation (SBRT) for refractory ventricular arrhythmia (VA) in Taiwanese patients. Three-dimensional electroanatomic maps, delayed-enhancement magnetic resonance imaging (DE-MRI), and dual-energy computed tomography (CT) were used to identify scar substrates. The main target volume was treated with a single radiation dose of 25 Gy and the margin volume received 20 Gy using simultaneous integrated boost delivered by the Varian TrueBeam system. Efficacy was assessed according to VA events recorded by an implantable cardioverter-defibrillator (ICD) or a 24-h Holter recorder. Pre- and post-radiation therapy imaging studies were performed. From February 2019 to December 2019, seven patients (six men, one woman; mean age, 55 years) were enrolled and treated. One patient died of hepatic failure. In the remaining six patients, at a median follow-up of 14.5 months, the VA burden and ICD shocks significantly decreased (only one patient with one ICD shock after treatment). Increased intensity on DE-MRI might be associated with a lower risk for VA recurrence, whereas dual-energy CT had lower detection sensitivity. No acute or minimal late adverse events occurred. In patients with refractory VA, SBRT is associated with a marked reduction in VA burden and ICD shocks, and DE-MRI might be useful for monitoring treatment effects. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/570610 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-021-89857-2 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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