https://scholars.lib.ntu.edu.tw/handle/123456789/570820
標題: | Relationship between serum gamma-glutamyl transferase level and colorectal adenoma | 作者: | TZU-CHAN HONG HUNG-CHIH YANG CHI-LING CHEN JIA-HORNG KAO CHUN-JEN LIU Chen M.-J Wang H.-Y Kuo Y.-C Yu L.-Y Hu K.-C. |
公開日期: | 2020 | 出版社: | Public Library of Science | 卷: | 15 | 期: | 10 | 來源出版物: | PLoS ONE | 摘要: | Background and aims Cost-effective serology tests may increase the predictive accuracy of colonoscopy for colorectal cancer screening. Reportedly, gamma-glutamyl transferase (GGT) is associated with oxidative stress and carcinogenesis and has been found to be elevated in the serum of cancer patients and colorectal adenoma tissue. We aimed to investigate the association between serum GGT levels and colorectal adenoma. Methods This single-center, health examination-based cohort enrolled 2475 subjects from 2006 to 2015. Baseline characteristics, laboratory data, bidirectional gastrointestinal endoscopy, and transabdominal ultrasonography were used to evaluate the severity of fatty liver. Results We found an elevated median GGT level in subjects with tubular adenoma compared with those without (23 IU/L and 20 IU/L, p<0.001). A GGT cutoff of ?20 IU/L reached a maximal Youden index in receiver operating curve (ROC) analyses. Subsequent regression analyses showed an odds ratio of 1.46 (95% CI 1.17-1.82, p<0.001) for age, body mass index, diabetes diagnosis, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and positive Helicobacter pylori urease test, all being associated with an increased incidence of colon adenoma. Subgroup analysis showed that the odds ratio (OR 1.27, 95% CI 1.15-1.68, p<0.001) is only significant and highest in patients with a negative or mild fatty liver and an ALT level of ?40 IU/L. Conclusions The results suggested a positive correlation of GGT with colon adenoma incidence and a predictive value with a cutoff point of >20 IU/L, which is within the normal range. The effect may be most prominent for those without steatohepatitis. ? 2020 Hong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092886091&doi=10.1371%2fjournal.pone.0240445&partnerID=40&md5=16e764dbdc96260d173c01ba7df04d89 https://scholars.lib.ntu.edu.tw/handle/123456789/570820 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0240445 | SDG/關鍵字: | gamma glutamyltransferase; low density lipoprotein cholesterol; triacylglycerol; gamma glutamyltransferase; gamma-glutamyltransferase, human; tumor marker; adult; age; Article; body mass; case control study; cholesterol blood level; cohort analysis; colorectal adenoma; controlled study; diabetes mellitus; diagnostic accuracy; diagnostic test accuracy study; disease association; disease severity; echography; fatty liver; female; gamma glutamyl transferase blood level; gastrointestinal endoscopy; Helicobacter infection; hospital based case control study; human; human tissue; incidence; laboratory test; major clinical study; male; normal value; odds ratio; predictive value; receiver operating characteristic; reference value; retrospective study; sensitivity and specificity; Youden index; adenoma; blood; clinical trial; colorectal tumor; follow up; middle aged; pathology; prognosis; risk factor; Adenoma; Biomarkers, Tumor; Case-Control Studies; Colorectal Neoplasms; Female; Follow-Up Studies; gamma-Glutamyltransferase; Humans; Incidence; Male; Middle Aged; Prognosis; Retrospective Studies; Risk Factors; ROC Curve |
顯示於: | 醫學系 |
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