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Viral factors affecting disease progression

Journal
Hepatitis B Virus and Liver Disease
Pages
119-133
Date Issued
2018
Author(s)
HUNG-CHIH YANG  
DOI
10.1007/978-981-10-4843-2_6
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045867116&doi=10.1007%2f978-981-10-4843-2_6&partnerID=40&md5=b79c645b0f6972c92080590782857fb3
https://scholars.lib.ntu.edu.tw/handle/123456789/570857
Abstract
The clinical outcomes of chronic hepatitis B virus (HBV) infection are heterogeneous, ranging from spontaneous seroconversion of hepatitis B surface antigen (HBsAg) to severe detrimental consequences, including hepatic failure, cirrhosis, and hepatocellular carcinoma (HCC). Four distinctive clinical phases are recognized in the natural course of chronic hepatitis B (CHB), namely, immune tolerance, immune clearance, inactive carrier, and HBV reactivation phases. Patients with prolonged immune active phases are prone to develop cirrhosis and HCC. Conventionally, serum HBV DNA level and HBeAg serostatus combined with serum ALT level are utilized to distinguish the disease states in the natural history of CHB. A number of other viral factors, including HBV genotype, several naturally occurring viral mutations as well as serum levels of HBsAg, HBV core-related antigen (HBcrAg), and total anti-HBc antibody, have been also associated with the long-term prognosis of CHB patients. All these qualitative and quantitative viral factors contribute to the disease progression. With the advance of technology, more new viral biomarkers may emerge in the future. Combination of all current and new viral factors may allow for more sophisticated delineation of disease states, the deeper mechanistic insight into the pathogenesis, and the more optimal management for patients. ? Springer Nature Singapore Pte Ltd. 2018. All rights reserved.
Subjects
Chronic hepatitis B; Hepatitis B virus; Natural history; Viral factors
SDGs

[SDGs]SDG3

Publisher
Springer Singapore
Type
book part

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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