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  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/570902
Title: Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation
Authors: Shan L
| Deng K
| Shroff N.S
| Durand C.M
| Rabi S.A
| HUNG-CHIH YANG 
| Zhang H
| Margolick J.B
| Blankson J.N
| Siliciano R.F.
Issue Date: 2012
Journal Volume: 36
Journal Issue: 3
Start page/Pages: 491-501
Source: Immunity
Abstract: 
Highly active antiretroviral therapy (HAART) suppresses HIV-1 replication but cannot eliminate the virus because HIV-1 establishes latent infection. Interruption of HAART leads to a rapid rebound of viremia, so life-long treatment is required. Efforts to purge the latent reservoir have focused on reactivating latent proviruses without inducing global T cell activation. However, the killing of the infected cells after virus reactivation, which is essential for elimination of the reservoir, has not been assessed. Here we show that after reversal of latency in an in vitro model, infected resting CD4 + T cells survived despite viral cytopathic effects, even in the presence of autologous cytolytic T lymphocytes (CTLs) from most patients on HAART. Antigen-specific stimulation of patient CTLs led to efficient killing of infected cells. These results demonstrate that stimulating HIV-1-specific CTLs prior to reactivating latent HIV-1 may be essential for successful eradication efforts and should be considered in future clinical trials. ? 2012 Elsevier Inc..
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863337769&doi=10.1016%2fj.immuni.2012.01.014&partnerID=40&md5=13dc15606417f38315811d318db4da2f
https://scholars.lib.ntu.edu.tw/handle/123456789/570902
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2012.01.014
metadata.dc.subject.other: antiretrovirus agent; article; CD4+ T lymphocyte; CD8+ T lymphocyte; cell killing; cell proliferation; controlled study; cytotoxic T lymphocyte; disease carrier; highly active antiretroviral therapy; human; human cell; Human immunodeficiency virus 1; immunostimulation; in vitro study; priority journal; T lymphocyte activation; virus latency; virus reactivation; Antiretroviral Therapy, Highly Active; CD4-Positive T-Lymphocytes; Coculture Techniques; Cytopathogenic Effect, Viral; Cytotoxicity, Immunologic; HIV Infections; HIV-1; Humans; Lymphocyte Activation; Proviruses; T-Lymphocytes, Cytotoxic; Virus Latency; Virus Replication
[SDGs]SDG3
Appears in Collections:醫學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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