https://scholars.lib.ntu.edu.tw/handle/123456789/571443
標題: | Phosphatidylinositol-3-kinase is involved in the antihyperglycemic effect induced by resveratrol in streptozotocin-induced diabetic rats | 作者: | Chi T.-C. Chen W.-P. Chi T.-L. Kuo T.-F. SHOEI-SHENG LEE Cheng J.-T. TZONG-FU KUO |
公開日期: | 2007 | 卷: | 80 | 期: | 18 | 起(迄)頁: | 1713-1720 | 來源出版物: | Life Sciences | 摘要: | Resveratrol, a polyphenolic substance found in grape skin, is proposed to account in part for the protective effect of red wine in the cardiovascular system. The aim of the present study is to investigate the action and possible mechanisms of resveratrol-produced regulation of plasma glucose in normal and diabetic rats including the animal model of streptozotocin (STZ)-induced and nicotinamide-STZ-induced (NA-STZ), and insulin-resistant diabetic rats. Resveratrol (p.o.) produced a hypoglycemic effect in a dose-dependent manner in normal and diabetic rats, and the insulin level was increased following resveratrol treatment in normal and NA-STZ diabetic rats. In insulin-deficient STZ-diabetic rats, resveratrol significantly lowered the plasma glucose 90?min after oral treatment, and the hypoglycemic effect was abolished by phosphatidyl-3-kinase (PI3K) inhibitors (LY294002 and wortmannin) which also inhibited resveratrol-induced Akt phosphorylation in soleus muscle of STZ-diabetic rats. The change in the protein expression level of glucose transporter subtype 4 (GLUT4) in the soleus muscle and phosphoenolpyruvate carboxykinase (PEPCK) in the liver of STZ-diabetic rats treated with resveratrol (3?mg/kg, p.o.) for 7?days was examined. Resveratrol normalized hepatic PEPCK expression and increased GLUT4 expression in the soleus muscle of STZ-diabetic rats. The results indicate that the mechanisms contributing to the hypoglycemic effect of resveratrol include insulin-dependent and insulin-independent pathway, and PI3K-Akt-signaling was involved in the latter mechanism to enhance glucose uptake in skeletal muscle. ? 2007 Elsevier Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33947321153&doi=10.1016%2fj.lfs.2007.02.002&partnerID=40&md5=a31baab3f0eb4de87ed9db2dcfa6261e https://scholars.lib.ntu.edu.tw/handle/123456789/571443 |
ISSN: | 243205 | DOI: | 10.1016/j.lfs.2007.02.002 | SDG/關鍵字: | 2 morpholino 8 phenylchromone; glucose; glucose transporter 4; insulin; nicotinamide; phosphatidylinositol 3 kinase; phosphoenolpyruvate carboxykinase (GTP); protein kinase B; resveratrol; wortmannin; analytic method; animal experiment; animal model; article; comparative study; controlled study; dose response; drug mechanism; glucose blood level; glucose transport; hypoglycemia; insulin blood level; insulin resistance; male; nonhuman; protein expression; protein phosphorylation; rat; signal transduction; streptozocin diabetes; 1-Phosphatidylinositol 3-Kinase; Androstadienes; Animals; Antioxidants; Blood Glucose; Carboxy-Lyases; Chromones; Diabetes Mellitus, Experimental; Glucose Transporter Type 4; Hypoglycemic Agents; Liver; Male; Morpholines; Muscle, Skeletal; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction; Stilbenes; Vitis; Animalia; Rattus; Vitaceae |
顯示於: | 藥學系 |
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