Preparation of secolycorines against acetylcholinesterase
Journal
Bioorganic and Medicinal Chemistry
Journal Volume
15
Journal Issue
2
Pages
1034-1043
Date Issued
2007
Author(s)
Abstract
5,6-Secolycorines possessing a 5,6-dihydrophenanthridine skeleton were facilely prepared from lycorine through chemical transformations, mainly including N-alkylation, Hofmann degradation type reaction, reductive cleavage of trichloroethylcarbonyl moiety, and hydrogenation. Several secolycorine derivatives showed potent inhibitory activity against acetylcholinesterase with the IC50 value at micromolar range and are more potent than galanthamine. © 2006 Elsevier Ltd. All rights reserved.
Type
journal article