Preparation and cytotoxic effect of ceanothic acid derivatives
Journal
Journal of Natural Products
Journal Volume
61
Journal Issue
11
Pages
1343-1347
Date Issued
1998
Author(s)
Abstract
Six ceanothane and 1-norceanothane derivatives (1, 2, 8-11) were prepared from ceanothic acid dibenzyl ester. These ring-A homologues of betulinic acid exhibited cytotoxic effects. Among these, 1-decarboxy-3-oxo- ceanothic acid (2) was found to be the most cytotoxic against OVCAR-3 and HeLa cancer cell lines, with an IC50 of 2.8 and 6.6 μg/mL, respectively, and an IC50 of 11.3 μg/mL against normal cell line FS-5.
SDGs
Other Subjects
1 decarboxy 3 oxoceanothic acid; 1 norceanothane derivative; betulic acid; ceanothane; ceanothic acid derivative; unclassified drug; article; cancer cell culture; drug cytotoxicity; drug isolation; drug structure; hela cell; structure activity relation; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Norsteroids; Plants, Medicinal; Spectrophotometry, Infrared; Triterpenes; Tumor Cells, Cultured
Type
journal article