Six lignans from Phyllanthus myrtifolius
Journal
Journal of Natural Products
Journal Volume
59
Journal Issue
11
Pages
1061-1065
Date Issued
1996
Author(s)
Abstract
Six lignans comprising phyllamyricins D (1), E (2), and F (3) and phyllamyricosides A (4), B (5), and C (6) were isolated in a continuing study of Phyllanthus myrtifolius. Compounds 1 and 2 are 2a-methoxy-4-aryl-2,3- naphthalides. Compounds 3-6 belong to the 4-arylnaphthalene class, with compounds 4-6 being O-β-glucosides. Their structures were elucidated on the basis of spectral analysis. Compound 4 increased the activity of HIV-1 reverse transcriptase by 65% at a concentration of 1.89 μM.
SDGs
Other Subjects
lignan derivative; phyllamyricin d; phyllamyricin e; phyllamyricin f; phyllamyricoside a; phyllamyricoside b; phyllamyricoside c; RNA directed DNA polymerase; unclassified drug; virus enzyme; article; controlled study; drug isolation; drug structure; enzyme activity; Human immunodeficiency virus 1; nonhuman; Phyllanthus; HIV-1 Reverse Transcriptase; Humans; Lignans; Magnetic Resonance Spectroscopy; Naphthalenes; Plants, Medicinal; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Human immunodeficiency virus; Human immunodeficiency virus 1; Phyllanthus myrtifolius
Type
journal article