Chemical Constituents from Dehaasia Triandra. II. 1 Five New Alkaloids, Secoxanthoplanine, Dehydroisocorydione, 11,8′-O-Bisisocorydine, (8,8′-R)- and (8,8′-S)- Bisisocorydine, isolated from the Leaves
Journal
Tetrahedron
Journal Volume
52
Journal Issue
19
Pages
6561-6568
Date Issued
1996
Author(s)
Abstract
A continuous study on the constituents from the leaves of Dehaasia tiandra Merr. resulted in the isolation of five additional novel alkaloids- secoxanthoplanine (1), dehydroisocorydione (2), (8,8′-R)- (3) and (8,8′-S)-bisisocorydine (4), and 11,8′-O-bisisocorydine (5). Compounds 3 and 4 are the first C-C linked bisaporphines at C-8 while 5 is the first bisaporphine with a diphenyl ether-linkage at C-8 and C-11 Besides elucidation based on a spectral analysis, the structures of 1, 3 and 4 were further confirmed by semisynthesis. Copyright © 1996 Elsevier Science Ltd.
Type
journal article