https://scholars.lib.ntu.edu.tw/handle/123456789/571830
標題: | Klyflaccisteroids K–M, bioactive steroidal derivatives from a soft coral Klyxum flaccidum | 作者: | Tsai Y.-Y Huang C.-Y Tseng W.-R Chiang P.-L Hwang T.-L Su J.-H Sung P.-J Dai C.-F Sheu, Jyh-Horng |
關鍵字: | antiinflammatory agent; cytotoxic agent; doxorubicin; elastase; klyflaccisteroid K; klyflaccisteroid L; klyflaccisteroid M; steroid; superoxide; unclassified drug; antiinflammatory agent; klyflaccisteroid K; klyflaccisteroid L; steroid; antiinflammatory activity; antineoplastic activity; Article; cancer cell; carbon nuclear magnetic resonance; controlled study; coral; drug structure; electrospray mass spectrometry; enzyme inhibition; heteronuclear multiple bond correlation; heteronuclear single quantum coherence; human; human cell; IC50; Klyxum flaccidum; neutrophil; nuclear Overhauser effect; proton nuclear magnetic resonance; animal; antagonists and inhibitors; Anthozoa; cell survival; chemistry; drug effects; tumor cell line; Animals; Anthozoa; Anti-Inflammatory Agents; Cell Line, Tumor; Cell Survival; Humans; Inhibitory Concentration 50; Neutrophils; Steroids; Superoxides | 公開日期: | 2017 | 卷: | 27 | 期: | 5 | 起(迄)頁: | 1220-1224 | 來源出版物: | Bioorganic and Medicinal Chemistry Letters | 摘要: | New steroids, klyflaccisteroids K–M (1–3), were isolated from a soft coral Klyxum flaccidum. Their structures were elucidated on the basis of extensive spectroscopic analysis. Klyflaccisteroid K (1) is the unique 9,11-secosteroid with a 5,8-epidioxy-9-ene functional group. Klyflaccisteroid L (2) has an unusual 11-norsteroid skeleton and is the first example of 11-oxasteroid isolated from natural sources. Cytotoxicity assay showed that 1 and 3 possessed moderate to weak cytotoxicity against these cancer cells. Compound 1 was also found to display significant anti-inflammatory activity of suppressing superoxide anion generation (O2 ? [rad]) and elastase release, and compound 3 was found to show notable anti-inflammatory activity toward inhibition of elasstase release, too. ? 2017 Elsevier Ltd |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85011029500&doi=10.1016%2fj.bmcl.2017.01.060&partnerID=40&md5=f3a711a16973ce60d3721c7b7a014d2e https://scholars.lib.ntu.edu.tw/handle/123456789/571830 |
ISSN: | 0960894X | DOI: | 10.1016/j.bmcl.2017.01.060 | SDG/關鍵字: | antiinflammatory agent; cytotoxic agent; doxorubicin; elastase; klyflaccisteroid K; klyflaccisteroid L; klyflaccisteroid M; steroid; superoxide; unclassified drug; antiinflammatory agent; klyflaccisteroid K; klyflaccisteroid L; steroid; antiinflammatory activity; antineoplastic activity; Article; cancer cell; carbon nuclear magnetic resonance; controlled study; coral; drug structure; electrospray mass spectrometry; enzyme inhibition; heteronuclear multiple bond correlation; heteronuclear single quantum coherence; human; human cell; IC50; Klyxum flaccidum; neutrophil; nuclear Overhauser effect; proton nuclear magnetic resonance; animal; antagonists and inhibitors; Anthozoa; cell survival; chemistry; drug effects; tumor cell line; Animals; Anthozoa; Anti-Inflammatory Agents; Cell Line, Tumor; Cell Survival; Humans; Inhibitory Concentration 50; Neutrophils; Steroids; Superoxides |
顯示於: | 海洋研究所 |
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