https://scholars.lib.ntu.edu.tw/handle/123456789/571832
標題: | Polyoxygenated klysimplexane- and eunicellin-based diterpenoids from the gorgonian Briareum violaceum | 作者: | Ahmed A.F Cheng Y CHANG-FENG DAI Sheu J.-H. |
關鍵字: | Briareum violaceum; Briarol; Eunicellin; Gorgonian; Klysimplexane | 公開日期: | 2021 | 卷: | 26 | 期: | 11 | 來源出版物: | Molecules | 摘要: | Three new polyoxygenated diterpenoids with a rare 4-isopropyl-1,5,8a-trimethylperhydrophenanthrane structure of the klysimplexane skeleton, briarols A-C (1-3), and one eunicellin-based diterpenoid, briarol D (4), were isolated from Briareum violaceum, a gorgonian inhabiting Taiwanese waters. The chemical structures of these compounds were determined by employing extensive analyses of NMR and high-resolution electrospray ionization mass spectrometry (HRESIMS) data. Metabolites 1-3 were found to possess the rarely found skeleton of the diterpenoid klysimplexin T. All isolated compounds showed very weak cytotoxic activity against the growth of three cancer cell lines. A plausible biosynthetic pathway for briarols A-C from the coexisting eunicellin diterpenoid briarol D (4) was postulated. ? 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107351764&doi=10.3390%2fmolecules26113276&partnerID=40&md5=366ace8033df5b5851a0f8ab25a5f837 https://scholars.lib.ntu.edu.tw/handle/123456789/571832 |
ISSN: | 14203049 | DOI: | 10.3390/molecules26113276 | SDG/關鍵字: | antineoplastic agent; diterpenoid; eunicellin; proton; animal; Anthozoa; chemistry; drug design; electrospray mass spectrometry; HT-29 cell line; human; IC50; medicinal chemistry; metabolism; neoplasm; nuclear magnetic resonance spectroscopy; powder; procedures; Taiwan; tumor cell line; water management; water pollutant; Animals; Anthozoa; Antineoplastic Agents; Cell Line, Tumor; Chemistry, Pharmaceutical; Diterpenes; Drug Design; HT29 Cells; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Neoplasms; Powders; Protons; Spectrometry, Mass, Electrospray Ionization; Taiwan; Water Pollutants, Chemical; Water Purification |
顯示於: | 海洋研究所 |
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