Irreversible Electroporation: A Novel Ultrasound-guided Modality for Non-thermal Tumor Ablation
Journal
Journal of Medical Ultrasound
Journal Volume
25
Journal Issue
4
Pages
195-200
Date Issued
2017
Author(s)
Abstract
Ultrasound-guided tumor ablation techniques have been proven to be highly effective and minimally invasive in the treatment of many diseases. Traditional approaches to ablation include microwave and radiofrequency techniques, cryotherapy, and high-intensity focused ultrasound. However, these methods are prone to heat-sink effects that can diminish the effectiveness of treatment and damage adjacent structures, such as bile ducts, blood vessels, the gallbladder, or bowel. Irreversible electroporation (IRE) is a non-thermal ablation modality that induces cell apoptosis through the application of high-voltage current. IRE is not limited by many of the limitation which affects conventional tumor ablation techniques, and is particularly useful in treating sensitive areas of the body. The article reviews the basics of ultrasound-guided technology, including its clinical applications and effectiveness in the treatment of tumors. ? 2017
SDGs
Other Subjects
acidosis; cancer recurrence; cardiovascular disease; clinical effectiveness; echography; electric conductivity; electrolyte disturbance; general anesthesia; human; irreversible electroporation; length of stay; liver cancer; muscle contraction; nonhuman; pancreas cancer; paralysis; patient monitoring; patient safety; pneumothorax; postoperative pain; Review; risk; thermal injury; treatment contraindication; treatment response; tumor ablation
Publisher
Elsevier (Singapore) Pte Ltd
Type
review