Characteristics of an alternative antibacterial biomaterial for mouthwash in the absence of alcohol
Journal
Journal of Dental Sciences
Journal Volume
14
Journal Issue
2
Pages
192-197
Date Issued
2019
Author(s)
Abstract
The purpose of this study was to investigate whether poly-gamma-glutamic acid (γ-PGA), a naturally derived biomaterial, was suitable as an alternative antibacterial mouthwash in the absence of alcohol. Three bacterial strains, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, were used for testing the antibacterial activity of mouthwashes. In addition, cell viability, cytotoxicity, and genotoxicity experiments were conducted for testing the toxicity of mouthwashes. We demonstrated that 10000 ppm of γ-PGA without alcohol could efficiently inhibit 99% of bacterial growth. In addition, γ-PGA did not cause any cytotoxicity or genotoxicity. 10000 ppm of γ-PGA in an alcohol-free mouthwash is an alternative biomaterial for mouthwashes.
SDGs
Publisher
Association for Dental Sciences of the Republic of China
Type
journal article