https://scholars.lib.ntu.edu.tw/handle/123456789/572762
標題: | Evaluation of motor coordination and antidepressant activities of cinnamomum osmophloeum ct. Linalool leaf oil in rodent model | 作者: | Chang H.-T Chang M.-L Chen Y.-T Chang S.-T Hsu F.-L Wu C.-C HUI-TING CHANG SHANG-TZEN CHANG |
公開日期: | 2021 | 卷: | 26 | 期: | 10 | 來源出版物: | Molecules | 摘要: | Cinnamomum plants (Lauraceae) are a woody species native to South and Southeast Asia forests, and are widely used as food flavors and traditional medicines. This study aims to evaluate the chemical constituents of Cinnamomum osmophloeum ct. linalool leaf oil, and its antidepressant and motor coordination activities and the other behavioral evaluations in a rodent animal model. The major component of leaf oil is linalool, confirmed by GC?MS analysis. Leaf oil would not induce the extra body weight gain compared to the control mice at the examined doses after 6 weeks of oral administration. The present results provide the first evidence for motor coordination and antidepressant effects present in leaf oil. According to hypnotic, locomotor behavioral, and motor coordination evaluations, leaf oil would not cause side effects, including weight gain, drowsiness and a diminishment in the motor functions, at the examined doses. In summary, these results revealed C. osmophloeum ct. linalool leaf essential oil is of high potential as a therapeutic supplement for minor/medium depressive syndromes. ? 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106886697&doi=10.3390%2fmolecules26103037&partnerID=40&md5=561eaecd01c3b77584575351af3dd4df https://scholars.lib.ntu.edu.tw/handle/123456789/572762 |
ISSN: | 14203049 | DOI: | 10.3390/molecules26103037 |
顯示於: | 森林環境暨資源學系 |
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