https://scholars.lib.ntu.edu.tw/handle/123456789/572908
標題: | Making concentrated pterostilbene highly bioavailable in pressure processed phospholipid nanoemulsion | 作者: | Sun F.-M Chou Y.-J Huang Q Hu J.-Y YU-WEN TING |
公開日期: | 2021 | 卷: | 9 | 期: | 2 | 起(迄)頁: | 1-15 | 來源出版物: | Processes | 摘要: | Pterostilbene, a dimethylether analog of resveratrol, has been found to have potent biological activity. However, the bioavailability of pterostilbene in the biological system is limited due to its poor solubility in an aqueous environment. A nanoemulsion system was designed for this purpose. Lecithin-based nanoemulsion was formed after 3 cycles through a high-pressure homogenizer at 500 psi. The rheological properties and particle size were measured using dynamic light scattering and a viscometer. The storage stabilities of the prepared formulation were determined based on its ability to maintain its particle size and loading concentration. According to the experimental results, the lecithin-based nanoemulsion system contained approximately 9.5% of pterostilbene. Over the 28-day stability test, the particle size, zeta potential, and encapsulation of pterostilbene in the nanoemulsion did not change significantly, indicating good storage stability. The positive effect of the prepared nanoemulsion system on bioavailability was studied and confirmed using in vitro lipolysis and a caco-2 monolayer model. ? 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101527547&doi=10.3390%2fpr9020294&partnerID=40&md5=a924897dd2f0e6c1ec1e597c154fc0ac https://scholars.lib.ntu.edu.tw/handle/123456789/572908 |
ISSN: | 22279717 | DOI: | 10.3390/pr9020294 |
顯示於: | 食品科技研究所 |
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